Relationship between optimal cooling temperature and cooling time required for the treatment of neurosurgical disease on the focal brain cooling

• Project/Area Number: 25870471
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery; Rehabilitation science/Welfare engineering
• Research Institution: Yamaguchi University
• Principal Investigator: INOUE Takao 山口大学, 医学部附属病院, 助教 (80513225)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 局所脳冷却 / てんかん / 脳波 / 脳温 / ニューロモデュレーション

Outline of Final Research Achievements

I have examined the effects of long-term focal brain cooling (LFBC) for intractable neurological disease.The relationship between the optimum cooling temperature and cooling time, LFBC has induced a serious impact on brain parenchyma by hypoperfusion. Therefore, when cooled neurons is likely to fall into ischemia, it was necessary to recover from the ischemic condition by raising the temperature of the brain surface. On the other hand, by increasing the cooling temperature, the brain has started to show again abnormal activity.
LFBC requires new modulation techniques for maintaining the cerebral blood flow by changing the cooling temperature. Further research is needed to develop a feedback brain temperature control technology using multimodal brain signals.

Research Products

• [Journal Article] Penicillin-induced epileptiform activity elevates focal brain temperature in anesthetized rats. (2013)
  • Author(s): Tokiwa T, Inoue T, Fujii M, Ishizuka S, Aou S, Kida H, Maruta Y, Yamakawa T, Nomura S, Suzuki M, Yamakawa T.
  • Journal Title: Neurosci Res. Volume: 76 Issue: 4 Pages: 257-260
  • DOI: 10.1016/j.neures.2013.05.001
  • Peer Reviewed
• [Presentation] てんかん焦点の局所脳冷却による脳循環代謝への影響 (2014)
  • Author(s): 井上貴雄、野村貞宏、藤井正美、賀業霆、丸田雄一、小泉博靖、末廣栄一、井本浩哉、山川烈、鈴木倫保
  • Organizer: Neuroscience2014
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-11
• [Presentation] ニューロモデュレーション『局所脳冷却』による難治性神経疾患治療 (2013)
  • Author(s): 井上貴雄、藤井正美、丸田雄一、井本浩哉、賀業霆、小泉博靖、野村貞宏、山川俊貴、大和田祐二、山川烈、鈴木倫保
  • Organizer: 第28回信号処理シンポジウム
  • Place of Presentation: 海峡メッセ下関（山口）
• [Presentation] ペニシリン誘発けいれん発作焦点領域における局所脳温度を上昇させる (2013)
  • Author(s): 井上貴雄、常盤達司、藤井正美、石塚智、粟生修司、木田裕之、丸田雄一、山川俊貴、野村貞宏、鈴木倫保、山川烈
  • Organizer: 第47回日本てんかん学会
  • Place of Presentation: 北九州国際会議場（福岡）
• [Presentation] けいれん誘発てんかんモデルに対する局所脳冷却の発作抑制効果と至適冷却温度 (2013)
  • Author(s): 井上貴雄、藤井正美、木田裕之、山川俊貴、丸田雄一、常盤達司、賀業霆、野村貞宏、大和田祐二、山川烈、鈴木倫保
  • Organizer: Neuro2013
  • Place of Presentation: 京都国際会館（京都）
• [Patent(Industrial Property Rights)] 硬膜下センサ (2014)
  • Inventor(s): 鈴木倫保、野村貞宏、丸田雄一、井上貴雄、山川俊貴、庭山雅嗣
  • Industrial Property Rights Holder: 山口大学、静岡大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-107467
  • Filing Date: 2014-05-23