Can fingolimod be treatment strategy for myasthenia gravis ?
| Project/Area Number |
25870477
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
Applied pharmacology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MATSUI Naoko 徳島大学, 大学病院, 診療支援医師 (10547954)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 重症筋無力症 / Finglimod / 胸腺 / recent thymic emigrant / fingolimod / Fingolimod |
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| Outline of Final Research Achievements |
We aimed to examine the effect of fingolimod on recent thymic emigrant (RTE). Peripheral blood mononuclear cells were obtained from 4 healthy subjects and 10 patients with multiple sclerosis (MS). Blood sampling for the patients with MS was performed before and after the administration of fingolimod (in 1, 6, and 12 months). CD3+CD4+ T, naive T (CD45RA+, CD45RO-), and memory T cells (CD45RA-, CD45RO+) were identified by FACS. We also analyzed naive T’s expression of CD31, a surrogate marker of RTE. The frequency of memory T cells was relatively increased, but that of RTE was decreased in MS. Effect of fingolimod on RTE continued over one year. Fingolimod act as a potent antagonist at sphingosine 1-phosphate receptor type 1 (S1P1) on lymphocytic emigration from secondary lymphoid organs as well as thymus. In myasthenia gravis (MG), removal of thymus results in RTEs. We speculate that fingolimod have a possibility of the pharmacological effect similar to thymectomy.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Are multifocal motor neuropathy patients underdiagnosed? An epidemiological survey in Japan.2014
Author(s)
Miyashiro A, Matsui N, Shimatani Y, Nodera H, Izumi Y, Kuwabara S, Baba M, Komori T, Sonoo M, Mezaki T, Kawamata J, Hitomi T, Imai T, Kohara N, Arimura K, Hashimoto S, Arisawa K, Kusunoki S, Kaji R
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Journal Title
Muscle Nerve
Volume: 49
Pages: 357-361
Related Report
Peer Reviewed / Open Access
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[Journal Article] Increased proinflammatory cytokines in sera of patients with multifocal motor neuropathy.2014
Author(s)
T. Furukawa, Noriko Matsui, K. Fujita, Ai Miyashiro, H. Nodera, Y. Izumi, Fumitaka Shimizu, K. Miyamoto, Y. Takahashi, Takashi Kanda, Susumu Kusunoki, Ryuji Kaji
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Journal Title
J Neurol Sci
Volume: 346
Issue: 1-2
Pages: 75-79
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Are multifocal motor neuropathy patients underdiagnosed? An epidemiological survey in Japan2014
Author(s)
Miyashiro A, Matsui N Shimatani Y, Nodera H, Izumi Y, Kuwabara S, Imai T, Baba M, Komori T, Sonoo M, Mezaki T, Kawamata J, Hitomi T, Kohara N, Arimura K, Hashimoto S, Arisawa K, Kusunoki S, Kaji R
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Journal Title
Muscle Nerve
Volume: 49
Pages: 357-361
Related Report
Peer Reviewed
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[Journal Article] Diagnostic spectrum of multifocal motor neuropathy2013
Author(s)
Matsui N, Miyashiro A, Shimatani Y, Nodera H, Izumi Y, Kuwabara S, Baba M, Komori T, Sonoo M, Mezaki T, Kawamata J, Hitomi T, Imai T, Kohara N, Arimura K, Arisawa K, Kusunoki S, Kaji R.
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Journal Title
Clinical and Experimental Neuroimmunology
Volume: 4
Pages: 210-215
Related Report
Peer Reviewed
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[Presentation] 当初ALSを疑われた高齢発症抗MuSK抗体陽性MGの一例2014
Author(s)
武藤 浩平, 酒井 和香, 松井 尚子, 沖 良祐, 宮本 亮介, 梶 誠兒, 武内 俊明, 丸山 恵子, 大崎 裕亮, 山本 伸昭, 宮城 愛, 野寺 裕之, 樋口 理, 和泉 唯信, 梶 龍兒
Organizer
第97回日本神経学会 中国・四国地方会
Place of Presentation
広島国際会議場(広島県広島市)
Year and Date
2014-12-06
Related Report
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