| Project/Area Number |
25870492
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
Pathobiological dentistry/Dental radiology
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| Research Institution | Kagoshima University (2015)
Kyushu University (2013-2014) |
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Principal Investigator |
Goto Yuichi 鹿児島大学, 医歯学域医学部・歯学部附属病院, 助教 (00637902)
|
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| Research Collaborator |
Kawano Shintaro 九州大学病院, 講師 (26463014)
Matsubara Ryota 九州大学病院, 助教 (60615798)
Sugiura Tsuyoshi 鹿児島大学, 医歯学域歯学系, 教授 (40322292)
Nakamura Seiji 九州大学, 大学院歯学研究院, 教授 (60189040)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | ΔNp63 / EMT / 口腔扁平上皮癌 / 浸潤 / 転移 / microRNA / 浸潤転移 / 上皮間葉転換 / 病理組織学的検討 / OSCC |
|---|
| Outline of Final Research Achievements |
Epithelial-to-mesenchymal transition (EMT), an essential developmental program, is through to be involved in tumor progression. ΔNp63, a homologue of p53, is described the association
with the EMT program, but the detail remains to be elucidate. In this study, we examined the roles of ΔNp63 in the EMT during progression of oral squamous cell carcinoma (OSCC).
Downregulation of ΔNp63 induced a mesenchymal cell-like phenotype and is possibly involved in invasion and metastasis in OSCC. Although further studies are needed to understand the complex roles of ΔNp63, revealing the functions of ΔNp63 in EMT during tumor progression will lead to new approaches for the treatment of OSCC.
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