| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
To demonstrate antiviral effects of intracellular antibody (intrabody) against internal proteins of influenza A virus in cultured cells and transgenic mice, experimental infections were conducted. In cultured cells expressing intrabody, the propagation of viruses of several subtypes were inhibited. In experimental infections with the mouse-adapted virus, all of transgenic mice expressing intrabody survived during the experimental period. These results indicate that the intrabody is sufficient to confer resistance against influenza A virus infections.
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