Effect of ALDH2 polymorphism on alcoholic hepatitis complicated with obesity or glucose intolerance
| Project/Area Number |
25870515
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
Gastroenterology
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| Research Institution | Saga University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | ALDH2 polymorphism / ALT / AST / GGT / Hemeoxyganase 1 / CYP2E1 / acetaldehyde / rs671 / heme oxygenase 1 / cancer development / ALDH2 / アセトアルデヒド / エタノール / 酸化ストレス / BMI / アディポカイン / ノックアウトマウス / 遺伝子多型 / 血清ALT / 肝 / ヘムオキシゲナーゼ |
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| Outline of Final Research Achievements |
Because serum transaminases elevate alcohol dose dependently as a consequence of liver injury, they serve as useful markers of excessive drinking. However, these markers are inadequate in individuals with ALDH2*2, because they show a different correlation with the amount of ethanol. For example, the serum ALT level could become even lower than the baseline after alcohol intake in ALDH2*2 carriers.
Importantly, excessive drinking is particularly dangerous in carriers of ALDH2*2 because the risk of alcohol-related cancer is much higher than that for ALDH2*1/*1 carriers. Without recognizing the genotype interaction on serum transaminase, the opportunity to warn people about potential cancer risks is missed owing to incorrect interpretation. This is particularly important in East Asian countries where approximately half of the population carries the ALDH2*2 allele. Some reasonable mechanisms have been suggested by experimental studies, including remodelling of detoxifying systems.
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Report
(5 results)
Research Products
(14 results)
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[Journal Article] Chronic Glutathione Depletion Confers Protection against Alcohol-induced Steatosis: Implication for Redox Activation of AMP-activated Protein Kinase Pathway.2016
Author(s)
Chen Y, Singh S, Matsumoto A, Manna SK, Abdelmegeed MA, Golla S, Murphy RC, Dong H, Song BJ, Gonzalez FJ, Thompson DC, Vasiliou V.
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Journal Title
Sci Rep.
Volume: －
Issue: 1
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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