| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
Bisphosphonate-related osteonecrosis of the jaw (BR-ONJ) mainly occurs following tooth extraction with patients taking oral and/or intravenous bisphosphonates. However, the mechanisms of BR-ONJ is unclear. The aim of this study was to address pathophysiology of BR-ONJ using mouse ONJ model in the combination of intravenous bisphosphonate treatment, chemotherapy and tooth extraction. This model indicated that immune suppression might be associated with BR-ONJ due to some immune-related cells and proteins. This findings may contribute to the development of ONJ therapy.
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