A genomic approach to the identification of transmission blocking antigens of malaria parasites
Project/Area Number |
25870525
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Parasitology (including sanitary zoology)
Genome biology
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Research Institution | Nagasaki University |
Principal Investigator |
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Research Collaborator |
ABKALLO Hussein
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | malaria / genomics / bioinformatics / LGS / WGS / gametocyte / vaccine / Gametocyte / Malaria / Genomics / Genetics / Bioinformatics / Vaccine |
Outline of Final Research Achievements |
This project has enabled a better understanding of the transmission dynamics of malaria parasites through manipulation of rodent malaria parasites in mosquitoes. We have developed a sophisticated methodology to identify genes that control important parts of the parasites life cycle. We have also shown that parasites may not become more dangerous through interaction with other parasite strains in nature.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Little Polymorphism at the K13 Propeller Locus in Worldwide Plasmodium falciparum Populations Prior to the Introduction of Artemisinin Combination Therapies2016
Author(s)
Mita T, Culleton R, Takahashi N, Nakamura M, Tsukahara T, Hunja CW, Zayar ZW, Hitake WW, Marma AS, Dysoley L, Ndounga M, Dzodzomenyo M, Akhwale WS, Kobayashi J, Uemura H, Kaneko A, Hombhanje F, Ferreira MU, Björkman A, Endo H, Ohashi J
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Journal Title
Antimicrobial Agents and Chemotherapy
Volume: 印刷中
Issue: 6
Pages: 3340-3347
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Clinical Presentation and Laboratory Diagnosis of the First Human Case in a Scottish Traveller2014
Author(s)
Cordina, C., Culleton, R., Jones, B.L., Smith, C., McConnachie, A., Coyne, M and Alexander, C.L Plasmodium knowlesi
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Journal Title
Journal of Travel Medicine
Volume: (In Press)
Issue: 5
Pages: 357-360
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] DNA from Pre-Erythrocytic Stage Malaria Parasites is Detectable by PCR in the Faeces and Blood of Hosts2014
Author(s)
Abkallo HM, Liu W, Hokama S, Ferreira PE, Nakazawa S, Maeno Y, Quang NT, Kaneko O, Huffman MA, Kawai S, Marchand RP, Carter R, B.H. H, Culleton R
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Journal Title
International Journal for Parasitology
Volume: 印刷中
Related Report
Peer Reviewed
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