| Project/Area Number |
25870538
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
Nerve anatomy/Neuropathology
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| Research Institution | Tohoku University (2014)
Kumamoto University (2013) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 海馬 / 神経新生 / ドラキシン / 軸索ガイダンス因子 / 神経栄養因子 / 軸索ガイダンス分子 / draxin / Draxin |
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| Outline of Final Research Achievements |
Granule cell production in the hippocampus dentate gyrus is fundamental to brain functions such as learning and memory. Although the previous study revealed that loss of draxin, which we previously identified as a neural repellent, leads to reduction in number of granule cells and hippocampal volume, little is known bout the mechanisms in which draxin regulates the hippocampal development. In this study, we report the dual role of draxin in hippocampal neurogenesis: (1) Draxin prevents the DCC-induced apoptosis of differentiating neurons by acting as a ligand for the dependence receptor, and promote neuronal survival through the receptors DCC and neogenin. (2) Draxin modulates differentiation of neuronal progenitors by attenuating the neuronal-differentiation-promoting activity of canonical Wnts. The draxin-mediated modulation would be useful for preventing depletion of progenitors, which vigorously proliferate, due to too rapid differentiation.
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