Research Project
Grant-in-Aid for Young Scientists (B)
We demonstrate the immune-regulatory effect of embryonic stem cell-derived dendritic cells (ES-DCs) using two models of autoimmune disease, namely non-obese diabetic (NOD) mice and experimental autoimmune encephalomyelitis (EAE). Treatment of pre-diabetic NOD mice with ES-DCs exerted almost complete suppression of diabetes development during the observation period. Development of EAE was also inhibited by the treatment with ES-DCs, and the treatment of EAE-induced mice with ES-DCs reduced the infiltration of inflammatory cells into the spinal cord and ES-DCs suppressed Th1 cells. Moreover, the ES-DC treatment did not affect T cell response to an exogenous antigen, and we observed the inhibition of differentiation and proliferation of Th1 cells by ES-DCs in vitro. These results suggest a clinical application for pluripotent stem cell-derived DCs as a therapy for T cell-mediated autoimmune diseases.
All 2014 2013
All Journal Article (1 results) (of which Peer Reviewed: 1 results, Open Access: 1 results, Acknowledgement Compliant: 1 results) Presentation (3 results)
PLoS One
Volume: 9 Issue: 12 Pages: e115198-e115198
10.1371/journal.pone.0115198
