The mechanism of laminar specification of cortical areas regulated by thalamic afferent projection
| Project/Area Number |
25870544
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
Nerve anatomy/Neuropathology
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| Research Institution | Kumamoto University |
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Principal Investigator |
Sato Haruka 熊本大学, 学内共同利用施設等, 特別研究員 (PD) (70625780)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 大脳皮質 / 層 / 領野 / 視床軸索 / 視床 / 軸索由来分子 / 脳・神経 / 視床軸索投射 |
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| Outline of Final Research Achievements |
In this research, we focused on the laminar specification during cortical area formation in mammalian brain, and examined how an extrinsic factor, thalamic afferents, play a role in this step. By analyzing mutant mice in which thalamic afferents are ablated, we found the neuronal number was decreased in layer 4, the target layer of thalamic afferents, of the target area. It is suggested that thalamic afferents refine area-specific laminar structure by regulating neuronal number.
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Report
(4 results)
Research Products
(4 results)
