| Project/Area Number |
25870550
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Infectious disease medicine
Virology
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
MURAKOSHI HAYATO 熊本大学, エイズ学研究センター, 産学官連携研究員 (60646123)
|
|---|
| Research Collaborator |
GATANAGA Hiroyuki
CHIKATA Takayuki
TAMURA Yoshiko
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 細胞傷害性T細胞 / HIV / HLA |
|---|
| Outline of Final Research Achievements |
We here sought to identify CD8+ T cells controlling HIV-1 variants in 401 Japanese individuals chronically infected with HIV-1 subtype B, in which protective alleles HLA-B*57 and HLA-B*27 are very rare, by using comprehensive and exhaustive methods. We identified 13 HIV-1 epitope-specific CD8+ T cells controlling HIV-1 in Japanese individuals though 9 of these epitopes were not previously reported. Nine of these epitopes were conserved among HIV-1 subtype B-infected individuals, whereas three out of 4 non-conserved epitopes were cross-recognized by the specific T cells. These findings indicate that these 12 epitopes are strong candidates of antigens for AIDS vaccine. The present study highlighted a strategy to identify CD8+ T cells controlling HIV-1 and demonstrated effective control of HIV-1 by those specific for 12 conserved or cross-reactive epitopes.
|
