| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
HLA-B*35:01 allele associates with high viral load (VL) in Japanese chronically HIV-1 clade B-infected individuals. We investigated the effect of cytotoxic T cell (CTL) responses to HLA-B*35:01-restricted epitopes on the control of HIV-1 in these individuals. Each CTL response to 4 out of 16 HLA-B*35:01-restricted epitopes was significantly but weakly associated with lower VL. The magnitude and the breadth of those 4 epitopes were significantly associated with lower VL. These results indicate even if the each response showed insufficient control of HIV-1, the multiple CTL responses to HLA-B*35:01-restricted epitopes, synergistically affect on the control of HIV-1 in HLA-B*35:01+ Japanese individuals. We found 2 significant association of the presence of HLA-B*35:01 allele with mutants, however HLA-B*35:01-restricted epitopes specific CTLs show cross-reactive with mutants. Those cross-reactive and WT specific CTLs contribute to the control of WT and mutant HIV-1 replication.
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