Research Project
Grant-in-Aid for Young Scientists (B)
In this project, we demonstrated the role of microRNA let-7a against skin fibrosis in systemic sclerosis (SSc). The let-7a was the potent regulator of type I collagen. The let-7a levels in dermal fibroblasts and sera of SSc patients were lower than those in healthy control. This down-regulation of let-7a in SSc led to the overexpression of type I collagen. We confirmed that the improvement of bleomycin-induced dermal thickening by let-7a administration. Investigation of more detailed mechanisms of miRNA-mediated regulation of collagen expression may lead to new therapeutic approach against systemic sclerosis.
All 2014 2013
All Journal Article (15 results) (of which Peer Reviewed: 15 results, Acknowledgement Compliant: 1 results)
Biosci Trends.
Volume: 8 Pages: 144-148
130004572597
PLoS One.
Volume: 22
European Journal of Dermatology
Volume: 24(4) Issue: 4 Pages: 760-6
10.1684/ejd.2014.2384
Clin Exp Rheumatol.
Volume: 32
J Dermatol.
Volume: 41 Issue: 7 Pages: 670-1
10.1111/1346-8138.12528
Br J Dermatol.
Volume: 171 Issue: 5 Pages: 1259-61
10.1111/bjd.13091
Int J Dermatol
Volume: 53 Pages: 300-304
Biosci Trends
Volume: 8 Pages: 64-67
130003397286
Eur J Dermatol
Volume: 23 Pages: 807-811
J Dermatol Sci
Volume: 72 Issue: 2 Pages: 134-41
10.1016/j.jdermsci.2013.06.018
J DermatoL
Volume: 40 Issue: 9 Pages: 715-9
10.1111/1346-8138.12218
Experimental Dermatology
Volume: 22 Issue: 7 Pages: 489-491
10.1111/exd.12173
J Dermatol
Volume: 40 Issue: 8 Pages: 632-634
10.1111/1346-8138.12203
Volume: 23 Pages: 160-167
Journal of Immunology
Volume: 190 Issue: 8 Pages: 3905-3915
10.4049/jimmunol.1200822