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The analysis of the risk using genotyping and the effect of precaution about orthopedic MRSA surgical site infection

Research Project

Project/Area Number 25870567
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical and hospital managemen
Orthopaedic surgery
Research InstitutionKagoshima University

Principal Investigator

Kawamura Hideki  鹿児島大学, 医学部・歯学部附属病院, 特例講師 (90647596)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsMRSA / 手術部位感染 / 遺伝子タイピング / 感染対策 / 手術部位感染サーベイランス / 整形外科 / サーベイランス
Outline of Final Research Achievements

MRSA is a frequent cause of orthopedic surgical site infections (SSIs). The approach comprising contact precautions for MRSA-positive patients and cefazolin-based antimicrobial prophylaxis stewardship in addition to active surveillance was associated with a significant decrease in the incidence of orthopedic MRSA SSIs. The prevalence of SCCmec II strains in the infection group was significantly higher than that in the colonization group. The most of clones associated with nosocomial transmission in this study were SCCmec II type. Preoperative MRSA active surveillance culture and decolonization were are effective for precaution of SSI due to preoperative nasal isolates by endogenous origin of MRSA. However, several patients with after decolonization developed SSI by exogenous transmission. Standard precaution and appropriate wound care must be necessary for prevention of SSI and contact precaution combined with genotyping may be helpful in preventing orthopedic SSIs.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (26 results)

All 2016 2015 2014 2013

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Acknowledgement Compliant: 2 results,  Open Access: 4 results) Presentation (16 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] A bundle that includes active surveillance, contact precaution for carriers, and cefazolin-based antimicrobial prophylaxis prevents methicillin-resistant Staphylococcus aureus infections in clean orthopedic surgery.2016

    • Author(s)
      Kawamura H, Matsumoto K, Shigemi A, Orita M, Nakagawa A, Nozima S, Tominaga H, Setoguchi T, Komiya S, Tokuda K, Nishi J
    • Journal Title

      Am J Infect Control

      Volume: 44 Issue: 2 Pages: 210-4

    • DOI

      10.1016/j.ajic.2015.09.014

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Epidemiological Analysis of Nosocomial MRSA Outbreaks Using Phage Open-Reading Frame Typing in a Tertiary-Care Hospital2016

    • Author(s)
      Kawamura H, Tokuda K, Imuta N, Kubota T, Koriyama T, Miyanohara H, Hashiguchi T, Kawano Y, Nishi J
    • Journal Title

      Japanese Journal of Infectious Diseases

      Volume: 69 Issue: 6 Pages: 523-524

    • DOI

      10.7883/yoken.JJID.2015.320

    • NAID

      130005284194

    • ISSN
      1344-6304, 1884-2836
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cut-off values of latent infection in patients with rapid migration following bipolar hip hemiarthroplasty.2016

    • Author(s)
      Setoguchi T, Kawakami H, Ishidou Y, Kawamura H, Nishi J, Yoshioka T, Kakoi H, Nagano S, Yokouchi M, Tanimoto A, Komiya S.
    • Journal Title

      BMC Musculoskelet Disord.

      Volume: 17 Issue: 1 Pages: 37-37

    • DOI

      10.1186/s12891-016-0876-3

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enrichment of bacteria samples by centrifugation improves the diagnosis of orthopaedics-related infections via real-time PCR amplification of the bacterial methicillin-resistance gene.2015

    • Author(s)
      Tsuru A, Setoguchi T, Kawabata N, Hirotsu M, Yamamoto T, Nagano S, Yokouchi M, Kakoi H, Kawamura H, Ishidou Y, Tanimoto A, Komiya S.
    • Journal Title

      BMC Res Notes.

      Volume: 8 Issue: 1 Pages: 288-288

    • DOI

      10.1186/s13104-015-1180-2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 整形外科領域感染症の臨床における問題点2015

    • Author(s)
      川村 英樹
    • Journal Title

      関節外科

      Volume: 34 Pages: 78-87

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analysis of surgical site infection after musculoskeletal tumor surgery: risk assessment using a new scoring system.2014

    • Author(s)
      Nagano S, Yokouchi M, Setoguchi T, Sasaki H, Shimada H, Kawamura I, Ishidou Y, Kamizono J, Yamamoto T, Kawamura H and Komiya S
    • Journal Title

      Sarcoma

      Volume: 2014 Pages: 645496-645496

    • DOI

      10.1155/2014/645496

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of Important Areas Identified by Infection Control Team Rounds at A University Hospital2013

    • Author(s)
      川村 英樹、折田 美千代、中川 彩、松元 一明、茂見 茜里、郡山 豊泰、西 順一郎
    • Journal Title

      Japanese Journal of Infection Prevention and Control

      Volume: 28 Issue: 1 Pages: 25-28

    • DOI

      10.4058/jsei.28.25

    • NAID

      130003371155

    • ISSN
      1882-532X, 1883-2407
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 全職種対応! 1日の流れに沿って教える 初めの初めの感染対策医師の1日 : 採血,診察,処置,記録2013

    • Author(s)
      川村 英樹
    • Journal Title

      Infection Control

      Volume: 22 Pages: 361-365

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 耐性菌感染情報ー耐性菌サーベイランスー2013

    • Author(s)
      川村 英樹
    • Journal Title

      Infection Control

      Volume: 22 Pages: 980-983

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 整形外科領域のMRSA感染制御2016

    • Author(s)
      川村英樹
    • Organizer
      第31回 日本環境感染学会
    • Place of Presentation
      国立京都国際会館(京都府 京都市)
    • Year and Date
      2016-02-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 積極的監視培養と手指衛生・接触予防策・術後感染予防抗菌薬適正使用遵守を中心とした整形外科領域MRSA手術部位感染対策の効果2015

    • Author(s)
      川村英樹、茂見茜里、折田美千代、中川彩、松元一明、小宮節郎、徳田浩一、西順一郎
    • Organizer
      MRSAフォーラム2015
    • Place of Presentation
      京王プラザホテル(東京都 新宿区)
    • Year and Date
      2015-07-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] MRSA非保菌者における整形外科領域MRSA手術部位感染発症リスクの検討2015

    • Author(s)
      川村英樹、茂見茜里 、松元一明 、徳田浩 、西順一郎
    • Organizer
      第63回日本化学療法学会
    • Place of Presentation
      京王プラザホテル(東京都 新宿区)
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 術後感染予防抗菌薬の投与期間適正化は整形外科領域MRSA手術部位感染を減少させる2014

    • Author(s)
      川村英樹, 茂見茜里, 郡山豊泰, 折田美千代, 中川 彩, 松元一明, 徳田浩一, 小宮節郎, 西 順一郎
    • Organizer
      第27回 日本外科感染症学会
    • Place of Presentation
      東京(東京コンファレンスセンター・有明)
    • Year and Date
      2014-12-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 整形外科領域感染症の臨床における問題点2014

    • Author(s)
      川村 英樹
    • Organizer
      第29回日本整形外科学会基礎学術集会
    • Place of Presentation
      鹿児島(城山観光ホテル)
    • Year and Date
      2014-10-09 – 2014-10-10
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Epidemiological analysis of MRSA infection risk at orthopedic surgical sites in non-MRSA carriers2014

    • Author(s)
      Kawamura H, Shigemi A, Matsumoto K, Koriyama T, Komiya S, Tokuda K and Nishi J,
    • Organizer
      54th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-09-05 – 2014-09-09
    • Related Report
      2014 Research-status Report
  • [Presentation] 整形外科領域におけるMRSA手術部位感染(SSI):非保菌者の発症要因に関する検討2014

    • Author(s)
      川村 英樹、茂見 茜里 、松元 一明 、徳田 浩一、西 順一郎、小宮 節郎
    • Organizer
      第37回日本骨・関節感染症学会
    • Place of Presentation
      東京(京王プラザホテル)
    • Year and Date
      2014-06-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Effect of Contact Precaution and Cefazolin-based Antimicrobial Prophylaxis Stewardship for Preventing Methicillin-resistant Staphylococcus aureus (MRSA) Surgical Site Infections (SSIs) in Clean Orthopedic Surgeries2014

    • Author(s)
      Kawamura H, Shigemi, Koriyama T, Matsumoto K, Orita M, Nagano S, Setoguchi T, Komiya S, Tokuda and Nishi J
    • Organizer
      The 24th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID)
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-05-10 – 2014-05-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 積極的監視培養と接触予防策遵守を中心とした整形外科領域MRSA手術部位感染対策の効果2014

    • Author(s)
      川村 英樹、茂見 茜里 、折田 美千代 、中川 彩、郡山 豊泰、松元 一明 、西 順一郎
    • Organizer
      第29回 日本環境感染学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 積極的監視培養を用いたサーベイランスによる当院ICUでのMRSA検出状況2014

    • Author(s)
      川村 英樹、安田 智嗣、垣花 泰之
    • Organizer
      第41回 日本集中治療医学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] MRSA感染症アウトブレイク疑い事例におけるPOT法とPFGE法による遺伝子タイピングの比較2013

    • Author(s)
      川村 英樹、藺牟田 直子、徳田 浩一、郡山 豊泰、松元 一明、茂見 茜里、西 順一郎
    • Organizer
      第87回日本感染症学会学術講演会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 鹿児島大学病院整形外科入院患者における薬剤耐性菌サーベイランス2013

    • Author(s)
      川村 英樹、小宮 節郎
    • Organizer
      第36回 日本骨関節感染症学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Effects of Care Bundle for Preventing Orthopedic Methicillin-resistant Staphylococcus aureus (MRSA) Surgical Site Infections (SSI)2013

    • Author(s)
      Kawamura H, Shigemi A, Koriyama T, Matsumoto K, Orita M, Komiya S, Tokuda K, Nishi J
    • Organizer
      IDWeek 2013
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 鹿児島大学病院ICUにおける MRSA・多剤耐性緑膿菌サーベイランス2013

    • Author(s)
      川村 英樹、茂見 茜里、郡山 豊泰、松元 一明、中村 健太郎、安田 智嗣、垣花 泰之、西 順一郎
    • Organizer
      第83回日本感染症学会 西日本地方会 学術集会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] ICUにおける感染管理と耐性菌対策 ICUにおける耐性菌サーベイランス2013

    • Author(s)
      川村 英樹、茂見 茜里、郡山 豊泰、松元 一明、折田 美千代、垣花 泰之、西 順一郎
    • Organizer
      第26回 日本外科感染症学会 学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Presentation] 整形外科領域における積極的監視培養と接触感染予防策遵守を中心としたMRSA手術部位感染対策の効果2013

    • Author(s)
      川村 英樹、茂見 茜里、折田 美千代、郡山 豊泰、松元 一明、冨永 博之、小宮 節郎、西 順一郎
    • Organizer
      第26回 日本外科感染症学会 学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Book] 今日の整形外科治療指針第7版2015

    • Author(s)
      川村 英樹
    • Total Pages
      4
    • Publisher
      医学書院
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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