| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
The dorsal striatum, which contains the dorsolateral striatum (DLS) and dorsomedial striatum (DMS), regurates the acquisition and performance of discrimination learning. However the mechanism by which the indirect pathway from the DLS or DMS regulates the learning processes of discriminative actions remains unclear. In current study, selective elimination of DLS- or DMS-indirect pathway were not changed in the acquisition of conditional discrimination. In contrast, ablation of the DLS- or DMS-indirect pathway transiently impaired the performance of conditional discrimination, showing a marked reduction in the selection accuracy. In addition, the probability of perseverative errors was significantly increased in the animals lacking the indirect pathway from the DMS, but not from the DLS.
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