The association between pentraxin 3 and inflammasome in left ventricular remodeling after myocardial infarction

• Project/Area Number: 25870584
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry; Cardiovascular medicine
• Research Institution: Fukushima Medical University
• Principal Investigator: SUZUKI Satoshi 福島県立医科大学, 医学部, 助教 (60536944)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ischemia reperfusion / neutrophils / cardiac remodeling / pentraxin 3 / 炎症 / 虚血再灌流 / 酸化ストレス / 血管新生 / 骨髄移植 / PTX3 / インフラマソーム / 心筋梗塞 / リモデリング

Outline of Final Research Achievements

The lack of pentraxin 3 (PTX3) produced from bone marrow-derived cells, but not from cardiac resident cells, contributes to inflammation after myocardial ischemia/reperfusion resulting in the increment of infarct size. PTX3 produced from bone marrow-derived cells has a crucial role for cardiac protection against myocardial ischemia/reperfusion injury via attenuating neutrophil infiltration and reactive oxygen species generation.

Research Products

• [Journal Article] Vasopressin V₂ Receptor Antagonist Tolvaptan Is Effective in Heart Failure Patients With Reduced Left Ventricular Systolic Function and Low Blood Pressure (2015)
  • Author(s): Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Abe Y, Saito T, Ohwada T, Suzuki H, Saitoh S, Kubota I, Takeishi Y
  • Journal Title: International Heart Journal Volume: 56 Issue: 2 Pages: 213-218
  • DOI: 10.1536/ihj.14-248
  • NAID: 130004941312
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] High Mobility Group Box 1 Promotes Angiogenesis from Bone Marrow-derived Endothelial Progenitor Cells after Myocardial Infarction (2015)
  • Author(s): Nakamura Y, Suzuki S, Shimizu T, Miyata M, Saitoh S, Kubota I, Takeishi Y
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 22 Issue: 6 Pages: 570-581
  • DOI: 10.5551/jat.27235
  • NAID: 130005078031
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Adaptive Servo-Ventilation Therapy Improves Long-Term Prognosis in Heart Failure Patients With Anemia and Sleep-Disordered Breathing (2014)
  • Author(s): Suzuki S, Yoshihisa A, Miyata M, Sato T, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: International Heart Journal Volume: 55 Issue: 4 Pages: 342-349
  • DOI: 10.1536/ihj.13-354
  • NAID: 130004941270
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Long-term effects and prognosis in acute heart failure treated with tolvaptan: The AVCMA trial (2014)
  • Author(s): Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Abe Y, Saito T, Ohwada T, Suzuki H, Saitoh S, Kubota I, Takeishi Y
  • Journal Title: BioMed Research International Volume: 2014 Pages: 1-8
  • DOI: 10.1155/2014/704289
  • Peer Reviewed / Open Access
• [Journal Article] High-Sensitivity Cardiac Troponin T Predicts Non-Cardiac Mortality in Heart Failure (2014)
  • Author(s): Nakamura Y, Yoshihisa A, Takiguchi M, Shimizu T, Yamauchi H, Iwaya S, Owada T, Miyata M, Abe S, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Circulation Journal Volume: 78 Issue: 4 Pages: 890-895
  • DOI: 10.1253/circj.CJ-13-1372
  • NAID: 130003391046
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Serum tenascin-C level is associated with coronary plaque rupture in patients with acute coronary syndrome (2014)
  • Author(s): Sakamoto N, Hoshino Y, Misaka T, Mizukami H, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Heart and Vessels Volume: 29 Issue: 2 Pages: 165-170
  • DOI: 10.1007/s00380-013-0341-2
  • Peer Reviewed
• [Journal Article] Serum cholinesterase is an important prognostic factor in chronic heart failure (2014)
  • Author(s): Sato T, Yamauchi H, Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Heart Vessels Volume: (in press) Issue: 2 Pages: 204-210
  • DOI: 10.1007/s00380-014-0469-8
  • Peer Reviewed
• [Journal Article] Impact of sleep-disordered breathing on myocardial damage and metabolism in patients with chronic heart failure (2014)
  • Author(s): Miyata M, Yoshihisa A, Yamauchi H, Owada T, Sato T, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Heart Vessels Volume: (in press) Issue: 3 Pages: 318-324
  • DOI: 10.1007/s00380-014-0479-6
  • Peer Reviewed
• [Journal Article] A case of acute myocardial infarction during perioperative period of non-cardiac surgery in a patient with antiphospholipid syndrome and a history of coronary artery bypass surgery (2014)
  • Author(s): Yokokawa T, Sugimoto K, Iwaya S, Suzuki S, Sakamoto N, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Journal of Cardiology Cases Volume: in press Issue: 5 Pages: 189-191
  • DOI: 10.1016/j.jccase.2014.01.008
  • Peer Reviewed
• [Journal Article] Cardiovascular function and prognosis of patients with heart failure coexistent with chronic obstructive pulmonary disease (2014)
  • Author(s): Yoshihisa A, Takiguchi M, Shimizu T, Nakamura Y, Yamauchi H, Iwaya S, Owada T, Abe S, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: J Cardiol Volume: (in press) Issue: 4 Pages: 256-264
  • DOI: 10.1016/j.jjcc.2014.02.003
  • Peer Reviewed
• [Journal Article] Comparisons of prognostic factors between young and elderly patients with chronic heart failure (2014)
  • Author(s): Sato T, Yamauchi H, Kanno Y, Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Geriatr Gerontol Int Volume: (in press) Issue: 4 Pages: 435-442
  • DOI: 10.1111/ggi.12293
  • Peer Reviewed
• [Journal Article] Long pentraxin PTX3 exacerbates pressure overload-induced left ventricular dysfunction. (2013)
  • Author(s): Suzuki S et al.
  • Journal Title: PLOS ONE Volume: 8 Issue: 1 Pages: e53133-e53133
  • DOI: 10.1371/journal.pone.0053133
  • Peer Reviewed
• [Journal Article] Acute heart failure volume control multicenter randomized (AVCMA) trial: Comparison of tolvaptan and carperitide (2013)
  • Author(s): Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Abe Y, Saito T, Ohwada T, Suzuki H, Saitoh S, Kubota I, Takeishi Y, on behalf of the AVCMA investigators
  • Journal Title: Journal of Clinical Pharmacology Volume: 53 Issue: 12 Pages: 1277-1285
  • DOI: 10.1002/jcph.197
  • Peer Reviewed
• [Journal Article] Adaptive servoventilation improves cardiorenal function and prognosis in heart failure patients with chronic kidney disease and sleep-disordered breathing (2013)
  • Author(s): Owada T, Yoshihisa A, Yamauchi H, Iwaya S, Suzuki S, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Journal of Cardiac Failure Volume: 19 Issue: 4 Pages: 225-232
  • DOI: 10.1016/j.cardfail.2013.03.005
  • Peer Reviewed
• [Journal Article] Clinical features of patients with decompensated heart failure after the Great East Japan Earthquake (2013)
  • Author(s): Yamauchi H, Yoshihisa A, Iwaya S, Owada T, Sato T, Suzuki S, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Am J Cardiol Volume: 112(1) Issue: 1 Pages: 94-99
  • DOI: 10.1016/j.amjcard.2013.02.057
  • Peer Reviewed
• [Journal Article] Deficiency of senescence marker protein 30 exacerbates angiotensin II-induced cardiac remodelling (2013)
  • Author(s): Misaka T, Suzuki S, Miyata M, Kobayashi A, Shishido T, Ishigami A, Saitoh S, Hirose M, Kubota I, Takeishi Y
  • Journal Title: Cardiovascular Research Volume: 9 Issue: 3 Pages: 461-470
  • DOI: 10.1093/cvr/cvt122
  • Peer Reviewed
• [Journal Article] Distinct Prognostic Factors in Patients With Chronic Heart Failure and Chronic Kidney Disease (2013)
  • Author(s): SatoT,YamauchiH,SuzukiS,YoshihisaA, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: International Heart Journal Volume: 54 Issue: 5 Pages: 311-317
  • DOI: 10.1536/ihj.54.311
  • NAID: 130003392047
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed
• [Journal Article] Impact of adaptive servo-ventilation on cardiovascular function and prognosis in heart failure patients with preserved left ventricular ejection fraction and sleep-disordered breathing (2013)
  • Author(s): Yoshihisa A, Suzuki S, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: European Journal of Heart Failure Volume: 15 Issue: 5 Pages: 543-550
  • DOI: 10.1093/eurjhf/hfs197
  • Peer Reviewed
• [Journal Article] Left ventricular plasty improved cardiac function in a case of takotsubo cardiomyopathy with persistent aneurysm (2013)
  • Author(s): Miyata M, Nakazato K, Sakamoto N, Suzuki S, Kamiyama Y, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Journal of Cardiology Cases Volume: 7 Issue: 5 Pages: e133-e136
  • DOI: 10.1016/j.jccase.2012.12.007
  • Peer Reviewed
• [Journal Article] New Angiotensin II Type 1 Receptor Blocker, Azilsartan, Attenuates Cardiac Remodeling after Myocardial Infarction (2013)
  • Author(s): Nakamura Y, Suzuki S, Saitoh S, Takeishi Y
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 36 Issue: 8 Pages: 1326-1331
  • DOI: 10.1248/bpb.b13-00194
  • NAID: 130003361508
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] Senescence marker protein 30 inhibits angiotensin II-induced cardiac hypertrophy and diastolic dysfunction (2013)
  • Author(s): Misaka T, Suzuki S, Miyata M, Kobayashi A, Ishigami A, Shishido T, Saitoh S, Kubota I, Takeishi Y
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 439 Issue: 1 Pages: 142-147
  • DOI: 10.1016/j.bbrc.2013.08.002
  • Peer Reviewed
• [Journal Article] Senescence marker protein 30 has a cardio-protective role in doxorubicin-induced cardiac dysfunction (2013)
  • Author(s): Miyata M, Suzuki S, Misaka T, Shishido T, Saitoh S, Ishigami A, Kubota I, Takeishi Y
  • Journal Title: PLoS One Volume: 8 Issue: 12 Pages: e79093-e79093
  • DOI: 10.1371/journal.pone.0079093
  • Peer Reviewed
• [Journal Article] Short-term use of adaptive servo ventilation improves renal function in heart failure patients with sleep-disordered breathing (2013)
  • Author(s): Yoshihisa A, Suzuki S, Owada T, Iwaya S, Yamauchi H, Miyata M, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Heart and Vessels Volume: 28 Issue: 6 Pages: 728-734
  • DOI: 10.1007/s00380-012-0303-0
  • Peer Reviewed
• [Journal Article] Sleep-Disordered Breathing Increases Risk for Fatal Ventricular Arrhythmias in Patients With Chronic Heart Failure (2013)
  • Author(s): Yamada S, Suzuki H, Kamioka M, Suzuki S, Kamiyama Y, Yoshihisa A, Saitoh S, Takeishi Y
  • Journal Title: Circulation Journal Volume: 77 Issue: 6 Pages: 1466-1473
  • DOI: 10.1253/circj.CJ-12-0836
  • NAID: 10031158876
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] 睡眠呼吸障害を伴う左室駆出率が保持された心不全患者におけるサーボ制御圧感知型人工呼吸器治療の心血管機能への影響 (2013)
  • Author(s): 義久精臣, 鈴木 聡, 竹石恭知
  • Journal Title: CAVI Now & Future Volume: 2 Pages: 30-33
• [Presentation] Non-invasive positive airway pressure improves mortality in heart failure patients with preserved left ventricular ejection fraction and sleep-disordered breathing (2014)
  • Author(s): Suzuki S, Yoshihisa A, Miura S, Takiguchi M, Shimizu T, Abe S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2014
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] The impact of plasma levels of receptor for advanced glycation end-products and high mobility group box 1 in patients with pulmonary hypertension (2014)
  • Author(s): Suzuki S, Nakazato K, Sugimoto K, Yoshihisa A, Yamaki T, Kunii H, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2014
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] High mobility group box 1 promotes angiogenesis from bone marrow-derived endothelial progenitor cells after myocardial infarction (2014)
  • Author(s): Nakamura Y, Suzuki S, Shimizu T, Miyata M, Shishido T, Ikeda K, Saitoh S, Kubota I, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2014
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Vasopressin V2 receptor antagonist tolvaptan is effective in heart failure patients with reduced left ventricular systolic function and low blood pressure (2014)
  • Author(s): Suzuki S, Yoshihisa A, Abe Y, Saitoh T, Ohwada T, Suzuki H, Saitoh S, Kubota I, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology 2014
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] 急性心不全におけるトルバプタンの有用性
  • Author(s): 鈴木 聡
  • Organizer: 心不全と水利尿勉強会
  • Place of Presentation: 神戸市
  • Invited
• [Presentation] 急性期のTolvaptanによる体液管理（AVCMA研究から）
  • Author(s): 鈴木 聡
  • Organizer: 第3回 心不全とVasopressin研究会
  • Place of Presentation: 横浜市
  • Invited
• [Presentation] 急性心不全におけるトルバプタンの有用性
  • Author(s): 鈴木 聡
  • Organizer: 水利尿薬学術講演会
  • Place of Presentation: 高松市
  • Invited
• [Presentation] サムスカの使用経験：入院早期におけるサムスカのメリット -AVCMA Studyから-
  • Author(s): 鈴木 聡
  • Organizer: Samsca® Heart Forum 2013 in Sapporo
  • Place of Presentation: 札幌市
  • Invited
• [Presentation] 急性心不全におけるトルバプタンの有用性
  • Author(s): 鈴木 聡
  • Organizer: 学術講演会 -新しい利尿薬 水利尿薬サムスカを考える-
  • Place of Presentation: 茨城県牛久市
  • Invited
• [Presentation] Acute heart failure volume control trial: the comparison of tolvaptan and carperitide
  • Author(s): Suzuki S, Yoshihisa A, Abe Y, Saito T, Ohwada T, Kubota I, Saitoh S, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology 2013
  • Place of Presentation: Amsterdam, The Netherlands
• [Presentation] 急性心不全におけるトルバプタンの有用性 ～AVCMA Studyから～
  • Author(s): 鈴木 聡
  • Organizer: 学術講演会
  • Place of Presentation: 会津若松市
  • Invited
• [Presentation] 急性心不全におけるトルバプタンの有用性 ～AVCMA Studyより～
  • Author(s): 鈴木 聡
  • Organizer: 第2回 水利尿薬と心不全を考える会
  • Place of Presentation: 秋田県由利本荘市
  • Invited
• [Presentation] 心不全における収縮不全と拡張不全のトピックス 心不全（収縮不全及び拡張不全）に合併する睡眠呼吸障害に対する陽圧換気療法の心・腎・血管機能に対する効果
  • Author(s): 義久精臣, 鈴木 聡, 竹石恭知
  • Organizer: 第61回 日本心臓病学会学術集会
  • Place of Presentation: 熊本市
• [Presentation] 循環器疾患を生活リズムと睡眠呼吸障害から考える 心不全に合併する睡眠呼吸障害の影響及び治療効果ー自律神経機能、不整脈への影響ー
  • Author(s): 義久精臣, 山田慎哉, 鈴木 聡, 鈴木 均, 竹石恭知
  • Organizer: 第61回 日本心臓病学会学術集会
  • Place of Presentation: 熊本市
• [Presentation] 抗リン脂質抗体症候群を合併した冠動脈バイパス術後患者の非心臓手術周術期に急性心筋梗塞を来した1例
  • Author(s): 横川哲朗, 杉本浩一, 岩谷章司, 鈴木 聡, 坂本信雄, 中里和彦, 鈴木 均, 斎藤修一, 竹石恭知
  • Organizer: 第61回 日本心臓病学会学術集会
  • Place of Presentation: 熊本市
• [Presentation] 入院早期の使用方法を考える：急性心不全におけるトルバプタンの有用性～AVCMA Studyから～
  • Author(s): 鈴木 聡
  • Organizer: Samsca Conference in Kanagawa
  • Place of Presentation: 横浜市
  • Invited
• [Presentation] 既存治療の問題点をサムスカで解決できるか？：サムスカの使用経験
  • Author(s): 花谷彰久, 滝村英幸, 鈴木 聡, 坂口大起
  • Organizer: Samsca® Heart Fourum 2013 in Osaka
  • Place of Presentation: 大阪市
• [Presentation] 急性心不全におけるトルバプタンの有用性
  • Author(s): 鈴木 聡
  • Organizer: 第2回 心不全治療と水利尿を考える会
  • Place of Presentation: 金沢市
  • Invited
• [Presentation] 急性心不全におけるトルバプタンの有用性～AVCMA Studyから～
  • Author(s): 鈴木 聡
  • Organizer: 相馬郡医師会学術講演会
  • Place of Presentation: 南相馬市
• [Presentation] サムスカの使用経験からわかること
  • Author(s): 白壁章宏, 重城健太郎, 田中 旬, 鈴木 仁, 鈴木 聡
  • Organizer: Samsca® Heart Forum 2013 in Tokyo
  • Place of Presentation: 東京
• [Presentation] 急性心不全におけるトルバプタンの有用性 ～AVCMA Studyから～
  • Author(s): 鈴木 聡
  • Organizer: 第6回 心不全と水利尿研究会
  • Place of Presentation: 大宮市
  • Invited
• [Presentation] 急性心不全におけるトルバプタンの有用性
  • Author(s): 鈴木 聡
  • Organizer: 第67回 国立病院総合医学会
  • Place of Presentation: 金沢市
  • Invited
• [Presentation] Senescence marker protein 30 has a cardio-protective role in doxorubicin-induced cardiac dysfunction
  • Author(s): Miyata M, Suzuki S, Misaka T, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2013
  • Place of Presentation: Dallas, Texas, USA
• [Presentation] Cyclic variation of heart rate score by holter ECG for screening sleep disordered breathing in heart failure patients
  • Author(s): Shimizu T, Yoshihisa A, Iwaya S, Miyata M, Abe S, Sato T, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2013
  • Place of Presentation: Dallas, Texas, USA
• [Presentation] Liver dysfunction assessed by model of end-stage liver disease excluding INR (MELD-XI) scoring system predicts adverse prognosis in heart failure
  • Author(s): Shimizu T, Yoshihisa A, Takiguchi M, Yamauchi H, Owada T, Iwaya S, Miyata M, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2013
  • Place of Presentation: Dallas, Texas, USA
• [Presentation] Adaptive servo-ventilation therapy improves long-term prognosis in heart failure patients with anemia and sleep-disordered breathing
  • Author(s): Suzuki S, Yoshihisa A, Shimizu T, Yamauchi H, Owada T, Miyata M, Abe S, Sato T, Yamaki T, Sugimoto K, Kunii H, Nakazto K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2013
  • Place of Presentation: Dallas, Texas, USA
• [Presentation] Vasopressin V2 receptor antagonist tolvaptan is effective in heart failure patients with reduced cardiac systolic function
  • Author(s): Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Abe Y, Saito T, Ohwada T, Saitoh S, Kubota I, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2013
  • Place of Presentation: Dallas, Texas, USA
• [Presentation] Severity of airflow limitation predicts exercise capacity and adverse clinical outcomes in chronic heart failure
  • Author(s): Sato T, Yamauchi H, Kanno Y, Suzuki S, Yoshihisa A, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2013
  • Place of Presentation: Dallas, Texas, USA
• [Presentation] Sleep-disordered breathing exacerbates ongoing myocardial damage in patients with heart failure
  • Author(s): Miyata M, Yoshihisa A, Shimizu T, Iwaya S, Owada T, Abe S, Sato T, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2013
  • Place of Presentation: Dallas, Texas, USA
• [Presentation] Impact of sleep-disordered breathing on vascular dysfunction and ventricular arrhythmias in heart failure patients
  • Author(s): Yoshihisa A, Suzuki S, Yamada S, Suzuki H, Takeishi Y
  • Organizer: 第17回 日本心不全学会学術集会
  • Place of Presentation: さいたま市
• [Presentation] Senescence marker protein 30 has protective effects on angiotensin II-induced cardiac hypertrophy and diastolic dysfunction
  • Author(s): Suzuki S, Misaka T, Saitoh S, Takeishi Y
  • Organizer: 第17回 日本心不全学会学術集会
  • Place of Presentation: さいたま市
• [Presentation] Cardiac function in heart failure patients with chronic obstructive pulmonary diseases
  • Author(s): Abe S, Yoshihisa A, Yamauchi H, Owada T, Miyata M, Sato T, Suzuki S, Oikawa M, Kobayashi A, Takeishi Y
  • Organizer: 第17回 日本心不全学会学術集会
  • Place of Presentation: さいたま市
• [Presentation] Adaptive servo ventilation improves cardio-renal function and prognosis in heart failure patients with chronic kidney disease and sleep disordered breathing
  • Author(s): Owada T, Yoshihisa A, Sato T, Suzuki S, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第17回 日本心不全学会学術集会
  • Place of Presentation: さいたま市
• [Presentation] Cardiac function in heart failure patients with periodic leg movements
  • Author(s): Takiguchi M, Yoshihisa A, Shimizu T, Yamauchi H, Miyata M, Sato T, Suzuki S, Oikawa M, Kobayashi A, Takeishi Y
  • Organizer: 第17回 日本心不全学会学術集会
  • Place of Presentation: さいたま市
• [Presentation] Utility of cyclic variation of heart rate score by holter ECG for screening sleep disordered breathing in heart failure patients
  • Author(s): Shimizu T, Yoshihisa A, Iwaya S, Miyata M, Abe S, Sato T, Suzuki S, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第17回 日本心不全学会学術集会
  • Place of Presentation: さいたま市
• [Presentation] Sleep-disordered breathing exacerbates ongoing myocardial damage in patients with heart failure
  • Author(s): Miyata M, Yoshihisa A, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第17回 日本心不全学会学術集会
  • Place of Presentation: さいたま市
• [Presentation] 急性心不全におけるトルバプタンの有用性 ～AVCMA Studyから～
  • Author(s): 鈴木 聡
  • Organizer: 東白川郡学術講演会
  • Place of Presentation: 福島県東白川郡
  • Invited
• [Presentation] 入院早期におけるサムスカⓇの役割と使い方：AVCMA試験からみえる、入院早期におけるサムスカⓇのメリットと長期的成績
  • Author(s): 鈴木 聡
  • Organizer: サムスカⓇ発売3周年記念全国講演会
  • Place of Presentation: 東京
• [Presentation] AVCMA試験からみえる、入院早期におけるサムスカのメリットと長期的成績
  • Author(s): 鈴木 聡
  • Organizer: 白河医師会学術講演会
  • Place of Presentation: 福島県西白河郡西郷村
  • Invited
• [Presentation] AVCMA試験からみえる、入院早期におけるサムスカのメリットと長期的成績
  • Author(s): 鈴木 聡
  • Organizer: 桐生・みどり市水利尿を考える会
  • Place of Presentation: 桐生市
  • Invited
• [Presentation] 既存治療の問題点をサムスカで解決できるか？：AVCMA試験からみえる、入院早期におけるサムスカのメリットと長期的成績
  • Author(s): 鈴木 聡
  • Organizer: Samsca® Heart Forum 2014 in Fukuoka
  • Place of Presentation: 福岡市
  • Invited
• [Presentation] 腎不全に心不全・呼吸不全を合併した患者の血液浄化法とその管理（血液浄化心不全研究会との合同企画): 心不全合併CKD患者のASV(Adaptive-Servo Ventilation)療法による心腎機能改善効果
  • Author(s): 義久精臣, 鈴木 聡, 竹石恭知
  • Organizer: 第41回 日本集中治療医学会学術集会
  • Place of Presentation: 京都市
• [Presentation] 心不全治療 循環器内科の立場から -AVCMA試験より-
  • Author(s): 鈴木 聡
  • Organizer: Otsuka Live on Seminar
  • Place of Presentation: Web (Live)
  • Invited
• [Presentation] 心不全における心腎関連と水利尿薬の可能性
  • Author(s): 鈴木 聡
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Acute heart failure volume control multicenter randomized (AVCMA) trial: comparison of tolvaptan and carperitide (Roundtable Discussion)
  • Author(s): Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Abe Y, Saito T, Ohwada T, Suzuki H, Saitoh S, Kubota I, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Cyclic variation of heart rate score by Holter ECG for screening sleep disordered breathing in heart failure patients
  • Author(s): Shimizu T, Yoshihisa A, Iwaya S, Nakamura Y, Miyata M, Abe S, Satoh T, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Sleep-disordered breathing exacerbates ongoing myocardial damage in patients with heart failure
  • Author(s): Takiguchi M, Yoshihisa A, Shimizu T, Yamauchi H, Owada T, Iwaya S, Nakamura Y, Miyata M, Abe S, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Influence of sleep disordered breathing on heart rate turbulence in heart failure patients
  • Author(s): Shimizu T, Yoshihisa A, Abe S, Takiguchi M, Iwaya S, Nakamura Y, Miyata M, Sato T, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Tolvaptan is effective in heart failure patients with reduced left ventricular systolic function
  • Author(s): Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Abe Y, Saitoh T, Ohwada T, Suzuki H, Saitoh S, Kubota I, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Model of end-stage liver disease excluding INR (MELD-XI) scoring system for liver function predicts adverse prognosis in heart failure
  • Author(s): Abe S, Yoshihisa A, Takiguchi M, Shimizu T, Yamauchi H, Owada T, Iwaya S, Miyata M, Satoh T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Long-term prognosis in acute decompensated heart failure patients treated with tolvaptan: The AVCMA trial
  • Author(s): Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Abe Y, Saitoh T, Ohwada T, Suzuki H, Saitoh S, Kubota I, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Cardiovascular function and prognosis of patients with heart failure coexistent with chronic obstructive pulmonary disease
  • Author(s): Yoshihisa A, Takiguchi M, Shimizu T, Nakamura Y, Yamauchi H, Owada T, Iwaya S, Miyata M, Abe S, Satoh T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] Cardio-vascular function in heart failure patients with periodic leg movements
  • Author(s): Takiguchi M, Yoshihisa A, Shimizu T, Yamauchi H, Owada T, Iwaya S, Nakamura Y, Miyata M, Abe S, Satoh T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第78回 日本循環器学会学術集会
  • Place of Presentation: 東京
• [Book] Aging and Heart Failure (2014)
  • Author(s): Suzuki S, Takeishi Y
  • Publisher: Springer