| Project/Area Number |
25870587
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
Kansei informatics
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| Research Institution | Ibaraki Prefectural University of Health Science |
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Principal Investigator |
Kaku Masami 茨城県立医療大学, 保健医療学部, 嘱託助手 (30646261)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | アルツハイマー病 / 参照記憶障害 / ストレス / 社会的孤立 / 自発的運動 / 強制的運動 / 逆転学習 / BDNF / ラット / Barnes迷路 / アミロイドβ蛋白質 / 参照記憶 / 運動の質 / アルツハイマー病モデルラット |
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| Outline of Final Research Achievements |
Alzheimer's disease (AD) is characterised by a progressive impairment of cognitive function. AD model rodents exhibit learning and memory deficits in a variety task. Recently, it is reported that stress intensified memory deficits in AD and AD model animals. Therefore, the fact that the task itself is so stressful makes it difficult to interpret data concerning β-amyloid (Aβ) -induced learning and memory deficits.
I assessed the lereaning and memory in AD model rats by the residential maze task (RMT) and the Barnes maze task (BMT).
I found that Aβ infused rats caused impairment of reference memory (retention period for 5 weeks) in RMT and BMT. Both Aβ and control rats were able to learn each task, but the ability to retention for long time in Aβ infused rats were significantly impaired. These results suggest that a continuous infusion of Aβ induces impairment of memory retention. Additionally, I found that the isolation rearing hastens the onset of reference memory deficit.
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