Functional imaging studies of alterations in self-representations in autism and schizophrenia

• Project/Area Number: 25870592
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science; Basic / Social brain science
• Research Institution: Tokyo Metropolitan University
• Principal Investigator: Hashimoto Ryuichiro 首都大学東京, 人文科学研究科(研究院), 准教授 (00585838)
• Co-Investigator(Renkei-kenkyūsha): JINBO Daiki 昭和大学, 医学部, 兼任講師 (60601317)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 脳機能イメージング / 統合失調症 / 自閉スペクトラム症 / セルフ / fMRI / 自己 / 自閉症

Outline of Final Research Achievements

The project conducted a series of fMRI experiments to examine functional alterations of neural substrates for self-related representation in autism spectrum disorders (ASD) and schizophrenia. In the ASD study, we examined functional connectivity during the resting-state and evaluation of self and other people. In the schizophrenia study, we examined relationship between the resting-state activity and auditory verbal hallucinations that are related to abnormalities of self-representations. The analyses revealed abnormalities in functional connectivity between brain regions in each of ASD and schizophrenia, indicating alterations of neural networks that may subserve self-related representations in these disorders.

Research Products

• [Journal Article] Alterations of local spontaneous brain activity and connectivity in adults with high-functioning autism spectrum disorder (2015)
  • Author(s): Itahashi T, Yamada T, Watanabe H, Nakamura M, Ohta H, Kanai C, Iwanami A, Kato N, Hashimoto R.
  • Journal Title: Mol Autism Volume: 6：30 Issue: 1 Pages: 1-14
  • DOI: 10.1186/s13229-015-0026-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Linked alterations in gray and white matter morphology in adults with high-functioning autism spectrum disorder: A multimodal brain imaging study (2015)
  • Author(s): Takashi Itahashi, Takashi Yamada, Motoaki Nakamura, Hiromi Watanabe, Bun Yamagata, Daiki Jimbo, Seiji Shioda, Miho Kuroda, Kazuo Toriizuka, Nobumasa Kato, Ryuichiro Hashimoto
  • Journal Title: NeuroImage: Clinical Volume: 7 Pages: 155-169
  • DOI: 10.1016/j.nicl.2014.11.019
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 自閉症スペクトラム障害の脳画像 (2013)
  • Author(s): 橋本龍一郎
  • Journal Title: 最新医学 Volume: 68 Pages: 110-119
• [Presentation] 脳画像法からみた自閉スペクトラム症の脳機能ネットワーク (2015)
  • Author(s): 橋本龍一郎
  • Organizer: 第39回日本高次脳機能障害学会学術総会
  • Place of Presentation: ベルサール渋谷ファースト（東京都渋谷区）
  • Year and Date: 2015-12-10
  • Invited
• [Presentation] 統合失調症における聴覚情報処理機能異常と幻聴との関連: fMRIを用いた検討 (2015)
  • Author(s): 長谷川澄、板橋貴史、岡田理恵子、谷将之、三村將、中村暖、岩波明、加藤進昌、橋本龍一郎
  • Organizer: 第４回精神科医学会学術大会
  • Place of Presentation: 沖縄コンベンションセンター（沖縄県宜野湾市）
  • Year and Date: 2015-10-08
• [Presentation] Alterations of insula functional anatomy in adults males with high-functioning autism spectrum disorderAlterations of insula functional anatomy in adults males with high-functioning autism spectrum disorder (2015)
  • Author(s): Yamada, T., Itahashi, T., Nakamura, M., Watanabe, H., Ohta, H., Kanai, C., Kato, N., & Hashimoto, R.
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸コンベンションセンター（兵庫県神戸市）
  • Year and Date: 2015-07-28
• [Presentation] 成人高機能自閉症の脳活動異常と局所的機能結合異常:安静時fMRIを用いた検討 (2014)
  • Author(s): 板橋貴史, 山田貴志, 渡部洋実, 中村元昭, 金井智恵子, 加藤進昌, 橋本龍一郎
  • Organizer: 第37回神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-12
• [Presentation] Altered activation for self- and other-referential processing in Autism Spectrum Disorder: A fMRI study. (2014)
  • Author(s): Hashimoto, R., Kato, N
  • Organizer: 21st World Conference of IACAPAP
  • Place of Presentation: ダーバン、南アフリカ
  • Year and Date: 2014-08-13
• [Presentation] Effects of Perspective on Brain Activation for Self- and Other-Referential Processing in Autism. (2014)
  • Author(s): Hashimoto, R., Yamada, T., Itahashi, T., Watanabe, H., Nakamura, M., Kanai, C., Iwanami, A., Kato, N.
  • Organizer: The 20th Annual Meeting of the organization on Human Brain Mapping
  • Place of Presentation: ハンブルグ、ドイツ
  • Year and Date: 2014-06-12
• [Presentation] Effects of Perspective on Brain Activation for Self- and Other-Referential Processing in Autism (2014)
  • Author(s): Hashimoto, R., Yamada, T., Itahashi, T., Watanabe, H., Nakamura, M., Kanai, C., Iwanami, A., Kato, N.
  • Organizer: the 2014 OHBM Annual Meeting
  • Place of Presentation: ドイツ ハンブルグ
• [Presentation] Neural substrates for cognitive control of metacognition in high-functioning adults with autism spectrum disorder (2013)
  • Author(s): Yamada, T., Nakamura, M., Itahashi, T., Watanabe, H., Kanai, C., Takayama, Y., Ohno, T., Tani, M., Iwanami, A., Kato, N., & Hashimoto, R
  • Organizer: International Symposium “Adolescent brain & mind and self-regulation”
  • Place of Presentation: 東京
• [Presentation] Joint gray and white matters’ alterations in adults with autism spectrum disorder revealed by joint independent component analysis (2013)
  • Author(s): Itahashi, T., Nakamura, M., Jimbo, D., Yamada, T., Watanabe, H., Kanai, C., Yamagata, B., Shioda, S., Toriizuka, K., Kato, N., & Hashimoto, R.
  • Organizer: 11th World Congress of Biological Psychiatry,
  • Place of Presentation: 京都
• [Book] カンデル神経科学 (2014)
  • Author(s): 橋本龍一郎
  • Total Pages: 19
  • Publisher: メディカル・サイエンス・インターナショナル