|Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|Outline of Final Research Achievements
The purpose of this study was to identify the role of tumor microenvironment in epithelial transformation of oral cancer cells under the hypoxic condition. Cell mortility and expression pattern of EMT-related proteins such as TWIST, Snail, and Slug in oral cancer cells were analyzed when these cells were cultured with or without CD11b+ myeloid cells and endothelial cells that are composed of tumor microenvironment. We found that oral cancer cells showed higher mortality in hypoxic condition than normoxia.