Investigation of GPNMB function in endoplasmic reticulum stress and oxidative stress responses

Research Project

Project/Area Number	25870605
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	General physiology Pharmacology in pharmacy
Research Institution	Gifu Pharmaceutical University
Principal Investigator	Tsuruma Kazuhiro 岐阜薬科大学, 薬学部, 講師 (50524980)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	小胞体ストレス / 神経変性疾患 / GPNMB / 小胞体ストレス応答機構 / GRP78 / スプライシング / 発現調節
Outline of Final Research Achievements	Endoplasmic reticulum (ER) stress is known to be associated with Alzheimer's disease, amyotrophic lateral sclerosis and glaucoma. Excessive ER stress causes cell death. In this study, I revealed that glycoprotein non-metastatic melanoma B (GPNMB), which is related to ALS and glaucoma, was upregulated by ER stress and GPNMB reduced the cell death induced by ER stress. GPNMB promoted the mRNA maturation of glucose-regulated protein 78 (GRP78/BiP) known as a molecular chaperone in ER.

Report

(4 results)