Clinical application of the latest proton beam technology based on potentially lethal damage repair and sublethal damage repair after proton beam irradiation

• Project/Area Number: 25870609
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science; Pathobiological dentistry/Dental radiology
• Research Institution: Nagoya City University
• Principal Investigator: Sugie Chikao 名古屋市立大学, 医学(系)研究科(研究院), 准教授 (80509258)
• Research Collaborator: SHIBAMOTO Yuta ; IWATA Hiromitsu ; HASHIMOTO Shingo ; OGINO Hiroyuki
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 亜致死損傷の回復 / 潜在致死損傷の回復 / 直接作用・間接作用 / 低線量率長時間持続γ線被曝 / 再酸素化 / 低線量率長時間持続被曝 / 一回大線量寡分割照射

Outline of Final Research Achievements

In order to clarify the biological response of tumor cells to proton beam irradiation, potentially lethal damage repair (PLDR) and sublethal damage repair (SLDR) after proton beam irradiation were investigated in comparison with those after X-irradiation. Compared to X-irradiation, PLDR and SLDR may take place to a lesser extent after proton beam irradiation. And we investigated the effects of prolonged exposure to very low dose-rate radiation on cultured tumor cells. Adaptive responses were detected after continuous culture on the hormesis sheets emitting very low dose-rate gamma rays.

Research Products

• [Journal Article] Partial-brain radiotherapy for primary central nervous system lymphoma: multi-institutional experience. (2016)
  • Author(s): Iwabuchi M, Shibamoto Y, Sugie C, Ayakawa S, Ogino H, Baba F
  • Journal Title: J Radiat Res Volume: 57(2) Issue: 2 Pages: 164-8
  • DOI: 10.1093/jrr/rrv085
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Definitive Radiotherapy Following Induction Chemotherapy for Hypopharyngeal Cancer: Selecting Candidates for Organ-Preserving Treatment Based on the Response to Induction Chemotherapy. (2016)
  • Author(s): Yanagi T, Shibamoto Y, Ogino H, Baba F, Murai T, Nagai A, Miyakawa A, Sugie C
  • Journal Title: Kurume Med J Volume: 印刷中
  • NAID: 130005148622
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of the Dynamic Jaw Mode in Helical Tomotherapy With Static Ports for Breast Cancer. (2015)
  • Author(s): Sugie C, Manabe Y, Hayashi A, Murai T, Takaoka T, Hattori Y, Iwata H, Takenaka R, Shibamoto Y
  • Journal Title: Technol Cancer Res Treat Volume: 14(4) Issue: 4 Pages: 459-65
  • DOI: 10.1177/1533034614558746
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Helical and Static-port Tomotherapy Using the Newly-developed Dynamic Jaws Technology for Lung Cancer. (2015)
  • Author(s): Manabe Y, Shibamoto Y, Sugie C, Hayashi A, Murai T, Yanagi T
  • Journal Title: Technol Cancer Res Treat Volume: 14(5) Issue: 5 Pages: 583-91
  • DOI: 10.7785/tcrtexpress.2013.600280
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Dose-volume histogram comparison between static 5-field IMRT with 18-MV X-rays and helical tomotherapy with 6-MV X-rays. (2015)
  • Author(s): Hayashi A, Shibamoto Y, Hattori Y, Tamura T, Iwabuchi M, Otsuka S, Sugie C, Yanagi T
  • Journal Title: J Radiat Res Volume: 56(2) Issue: 2 Pages: 338-45
  • DOI: 10.1093/jrr/rru111
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 陽子線の潜在性致死障害・亜致死障害からの回復 in vitro study (2016)
  • Author(s): 橋本眞吾、杉江愛生、岩田宏満、他橋本眞吾、杉江愛生、岩田宏満、荻野浩幸、大町千尋、安井啓祐、溝江純悦、芝本雄太
  • Organizer: 日本医学放射線学会第159回中部地方会
  • Place of Presentation: 名古屋市立大学（愛知県名古屋市）
  • Year and Date: 2016-01-31
• [Presentation] Biological effects of a radiation hormesis sheet emitting very low dose-rate gamma rays. (2015)
  • Author(s): Sugie C, Shibamoto Y, Hashimoto S, Tsuchiya T, Matsuo M, Takaoka T, Ogawa Y, Kawai T, Hirose Y, Iwata H
  • Organizer: 日本放射線腫瘍学会第28回学術大会
  • Place of Presentation: ベイシア文化ホール（群馬県前橋市）
  • Year and Date: 2015-11-20
• [Presentation] The influence of using the dynamic jaw mode on dose distribution of a target with longitudinal respiratory motion in helical tomotherapy: a phantom study. (2015)
  • Author(s): Sugie C, Murai T, Fukuma H, Eguchi Y, Tsuchiya T, Hirose Y, Manabe Y, Hayashi A, Takaoka T, Shibamoto Y
  • Organizer: 日本放射線腫瘍学会第28回学術大会
  • Place of Presentation: ベイシア文化ホール（群馬県前橋市）
  • Year and Date: 2015-11-20
• [Presentation] in vitro における低線量率長時間持続被曝の影響 (2015)
  • Author(s): 杉江愛生、芝本雄太、橋本眞吾、土屋貴裕、松尾政之、高岡大樹、小川靖貴、河合辰哉、廣瀬保次郎、岩田宏満
  • Organizer: 日本医学放射線学会第158回中部地方会
  • Place of Presentation: アクトシティ浜松 コングレスセンター（静岡県浜松市）
  • Year and Date: 2015-07-05
• [Book] Intensity-Modulated Radiation Therapy (2015)
  • Author(s): Nishimura Y, Komaki R, Shibamoto Y. Sugie C, Ogino H, Tomita N
  • Total Pages: 473
  • Publisher: Springer