Investigation of kisspeptin-regulating mechanism by suckling stimulus
| Project/Area Number |
25870621
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including histology/embryology)
Obstetrics and gynecology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
YAMADA Shunji 京都府立医科大学, 医学(系)研究科(研究院), 講師 (40454079)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | キスペプチン / 授乳期 / 吸乳刺激 / 生殖内分泌 / 神経回路 / カルシトニン遺伝子関連ペプチド / 脚周囲核 / 神経経路 |
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| Outline of Final Research Achievements |
Kisspeptin is the head of neural peptide regulating reproductive functions, and the expression is remarkably suppressed by suckling stimulus from pups in lactating mother rats who are inhibited reproductive function. The present project was undertaken to investigate what kind of mechanism does suckling stimulus suppress kisspeptin expression through. The present study demonstrated that calcitonin gene-related peptide (CGRP) in the thalamus and brainstem were increased during lactation and thalamic CGRP neurons were activated by suckling stimulus.
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Report
(3 results)
Research Products
(14 results)
