Roles of inflammasome in the development of NSAID-induced enteropathy

• Project/Area Number: 25870624
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology; Experimental pathology
• Research Institution: Osaka City University
• Principal Investigator: Nadatani Yuji 大阪市立大学, 大学院医学研究科, 後期臨床研究医 (00634007)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 小腸傷害 / インフラマソーム / NSAIDｓ小腸傷害 / 小腸 / NSAIDｓ / 消化管傷害 / NSAIDs

Outline of Final Research Achievements

The Aim of this study is to investigate the role of inflammasomes in Non-steroidal anti-inflammatory drugs (NSAIDs) induced enteropathy.
This study showed that the NLRP3 inflammasome-associated IL-1beta plays a critical role in NSAIDs-induced small intestinal enteropathy. In addition, the TLR4 and P2X7 signalings plays an improtant roles in developing this NLRP3 inflammasome associated enteropathy.

Research Products

• [Journal Article] Mechanisms of NLRP3 inflammasome activation and its role in NSAID-induced enteropathy (2015)
  • Author(s): A Higashimori, T Watanabe, Y Nadatani, S Takeda, K Otani, T Tanigawa, H Yamagami, M Shiba, K Tominaga, Y Fujiwara and T Arakawa
  • Journal Title: Mucosal Immunology Volume: 89
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Non-Steroidal Anti-Inflammatory Drugs Injure the Small Intestine Through NLRP3 Inflammasome Activation (2014)
  • Author(s): Akira Higashimori, Toshio Watanabe, Yuji Nadatani, Shogo Takeda, Tetsuya Tanigawa, Hirokazu Yamagami, Masatsugu Shiba, Kenji Watanabe, Kazunari Tominaga, Yasuhiro Fujiwara, Tetsuo Arakawa
  • Organizer: Digestive disease week 2014
  • Place of Presentation: ワシントンDC（アメリカ合衆国）
  • Year and Date: 2014-05-06
• [Presentation] Non-steroidal Anti-inflammatory Drugs-induced small intestinal damage is mediated by the NLRP3 inflammasome and TLR4. (2014)
  • Author(s): Akira Higashimori, Toshio Watanabe, Tetsuya Tanigawa, Shogo Takeda, Yuji Nadatani, Koji Otani, Hirokazu Yamagami, Kenji Watanabe, Kazunari Tominaga, Yasuhiro Fujiwara, Tetsuo Arakawa
  • Organizer: Digestive disease week 2014
  • Place of Presentation: シカゴ マコーミックプレイス （アメリカ合衆国）