Synthesis and Biological Evaluation of Ammonioundecahydro-closo-dodecaborate Containing Pharmaceuticals for BNCT
| Project/Area Number |
25870625
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
Drug development chemistry
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | BNCT / ホウ素薬剤 / ホウ素アミノ酸 / ホウ素クラスター / 癌 |
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| Outline of Final Research Achievements |
Boron neutron capture therapy (BNCT) has attracted attention as a potential treatment for malignant brain tumors. Although many kinds of boron-containing compounds have been reported as boron delivery agents (boron carriers) for BNCT, only two compounds are used for the treatment of brain tumors via BNCT. In order to develop the novel boron pharmaceuticals for BNCT, we studied the following three research theme; i) development of novel reaction for dodecaborate, ii) synthesis of novel dodecaborate containing boron pharmaceuticals, iii) evaluation of novel boron pharmaceuticals. In the results of above study, the useful boron compound for BNCT is synthesized by the novel reaction method for dodecaborate.
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Report
(4 results)
Research Products
(6 results)
