Investigation into an immune cell therapy for oral cancer associated with gamma delta T cells and the MICA gene
Project/Area Number |
25870633
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
Immunology
|
Research Institution | Nara Medical University |
Principal Investigator |
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | γδT細胞 / 口腔がん / 免疫細胞療法 / MICA遺伝子 / 1免疫細胞療法 |
Outline of Final Research Achievements |
γδT cells are lymphocytes responsible for anti-cancer immunity; however, because they only comprise a small percentage of the peripheral blood cells in humans, their anti-tumor action has not been sufficiently demonstrated. The present study investigated the cytotoxicity of in-vitro cultured γδT cells towards oral cancer cells. The methods and results were as follows: (1) Peripheral blood was cultured and the γδT cells activated using zoledronic acid and IL-2. (2) The cytotoxicity of γδT cells towards oral cancer cells appeared to be related to MICA gene polymorphisms. (3) Combining γδT cells with the molecular targeted drug cetuximab increased their cytotoxicity, suggesting the utility of these agents in immunotherapy.
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Report
(4 results)
Research Products
(7 results)