New development of pulmonary fibrosis therapy based on pulmonary drug delivery technology with fibrinolysis functions
| Project/Area Number |
25870654
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Physical pharmacy
Pharmacology in pharmacy
|
|---|
| Research Institution | Hokkaido Pharmaceutical University School of Pharmacy |
|---|
Principal Investigator |
Chono Sumio 北海道薬科大学, 薬学部, 教授 (90347790)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 肺線維症 / 肺線維芽細胞 / ピルフェニドン / bFGF修飾リポソーム / 経気道投与型ドラッグデリバリーシステム / コラーゲン産生 / 経気道局所治療 / リポソーム |
|---|
| Outline of Final Research Achievements |
Liposomal pirfenidone as a anti-fibrotic drug formulation was designed and prepared, and its efficacy as a pulmonary drug delivery system for treatment of pulmonary fibrosis was evaluated. Liposomal pirfenidone was efficiently delivered to fibroblasts and it inhibited collagen production in fibroblasts. This study suggests that aerosol-based liposomal pirfenidone is a new therapeutic strategy.
|
Report
(4 results)
Research Products
(13 results)
