| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
In this study, found possibility the osteoclasts responsible for bone resorption in bone metabolism is increase osteoclast differentiation by mechanical stress such as orthodontics. Osteoclast precursor cell-like cells ‘‘RAW264.7 cells’’ was decreased IRF-8mRNA by transiently of mechanical stress and increased NFATc1mRNA . However, After applying transiently mechanical stresses, Increased by IRF-8 with time was supressed osteoclast differentiation .If continuous mechanical stress is applied is considered to NFATc1 in the cytoplasm increases, suggesting that differentiation is easily was enhanced.
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