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Inhibitors of yellow pigment production by Staphylococcus aureus

Research Project

Project/Area Number 25870704
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Drug development chemistry
Bioorganic chemistry
Research InstitutionKitasato University

Principal Investigator

FUKUDA Takashi  北里大学, 薬学部, 助教 (30348586)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
KeywordsMRSA / 黄色色素生成阻害剤 / 活性物質 / 抗感染症 / 黄色ブドウ球菌 / 構造活性相関
Outline of Final Research Achievements

It is well known that S. aureus produces a yellow pigment called staphyloxanthin. Recently, several research groups reported that staphyloxanthin is one of the important virulent factors of S. aureus and the staphyloxanthin biosynthetic pathway of S aureus could be a new potential target to combat MRSA infection. Therefor, we established the screening method and started to find the inhibitors of yellow pigment production. Under this screening, citridone A and graphiumins A to H were found as inhibitors from the culture broth of microorganisms. In the case of citridone A, a common 4,5,6a-trimethyl-4,6a-dihydro-3aH-cyclopentafuran skeleton was necessary to show biological activities.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (5 results)

  • [Journal Article] Graphiumins, New Thiodiketopiperazines from the Marine-Derived Fungus Graphium sp. OPMF002242015

    • Author(s)
      Takashi Fukuda, Minori Shinkai, Eri Sasaki, Kenichiro Nagai, Yuko Kurihara, Akihiko Kanamoto, Hiroshi Tomoda
    • Journal Title

      Journal of Antibiotics

      Volume: 印刷中 Issue: 10 Pages: 620-627

    • DOI

      10.1038/ja.2015.41

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Synthesis and Biological Activity of Citridone A and Its Derivatives2014

    • Author(s)
      Takashi Fukuda, Kenta Shimoyama, Tohru Nagamitsu, Hiroshi Tomoda
    • Journal Title

      Journal of Antibiotics (Tokyo)

      Volume: 印刷中 Issue: 6 Pages: 445-450

    • DOI

      10.1038/ja.2014.14

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Terretonin G, a New Sesterterpenoid Antibiotic from Marine-Derived Aspergillus sp. OPMF002722014

    • Author(s)
      Takashi Fukuda, Yuko Kurihara, Akihiko Kanamoto, Hiroshi Tomoda
    • Journal Title

      Journal of Antibiotics (Tokyo)

      Volume: 印刷中 Issue: 8 Pages: 593-595

    • DOI

      10.1038/ja.2014.46

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 黄色ブドウ球菌が生産する黄色色素の生成阻害活性物質2015

    • Author(s)
      福田隆志、佐々木恵里、内田龍児、供田洋
    • Organizer
      日本薬学会 135 年会
    • Place of Presentation
      デザイン・クリエイティブセンター神戸(兵庫県)
    • Year and Date
      2015-03-28 – 2015-03-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Biological Activity of Citridone A2015

    • Author(s)
      Takashi Fukuda,
    • Organizer
      SIMB
    • Place of Presentation
      San Diego, CA, US
    • Year and Date
      2015-01-10 – 2015-01-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] raphiumins, New Thiodiketopiperazines from Marine-derived Fungus Graphium sp. OPMF002242014

    • Author(s)
      Takashi Fukuda, Akihiko Kanamoto, Hiroshi Tomoda
    • Organizer
      Gordon Research Conferences
    • Place of Presentation
      Ventura, CA, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 海洋由来真菌 OPMF00272 株が生産する新規化合物 terretonin G に関する研究2014

    • Author(s)
      福田隆志、佐々木望美、栗原祐子、金本昭彦、供田洋
    • Organizer
      日本薬学会第 134 年会
    • Place of Presentation
      熊本市総合体育館 (熊本県熊本市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 海洋由来真菌 OPMF00224 株が生産する新規化合物 graphiumin 類に関する研究2014

    • Author(s)
      佐々木恵里、福田隆志、新開みのり、栗原祐子、金本昭彦、供田洋
    • Organizer
      日本薬学会第 134 年会
    • Place of Presentation
      熊本市総合体育館 (熊本県熊本市)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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