How does miR-375 promote invasion in non-small-cell lung cancer?
Project/Area Number |
25870716
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Tumor biology
Respiratory organ internal medicine
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Research Institution | Keio University |
Principal Investigator |
YODA Satoshi 慶應義塾大学, 医学部, 共同研究員 (30468491)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | 肺癌 / micro RNA / microRNA / miR-375 / Claudin-1 / 標的遺伝子 |
Outline of Final Research Achievements |
This study was performed concerning microRNAs which regulate the function of genes. We discovered that miR-375, one of microRNAs, regulates the gene named Claudin-1 in non-small cell lung cancer cells. We also reported that stronger expression of miR-375 was related to faster movement of cells and lung cancer patients with stronger expression of miR-375 had shorter survivals. It suggested that miR-375 is involved in metastasis of cancers.
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Report
(3 results)
Research Products
(2 results)
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[Journal Article] Claudin-1 is a novel target of miR-375 in non-small-cell lung cancer.2014
Author(s)
Yoda S, Soejima K, Hamamoto J, Yasuda H, Nakayama S, Satomi R, Terai H, Ikemura S, Sato T, Naoki K, Betsuyaku T.
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Journal Title
Lung Cancer
Volume: 85
Issue: 3
Pages: 366-372
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Claudin-1, a novel target of miR-375 in non-small cell lung cancer.2014
Author(s)
Yoda S, Soejima K, Yasuda H, Sato T, Arai D, Ohgino K, Ishioka K, Tani T, Oashi A, Kuroda A, Nishino M, Miyawaki M, Hamamoto J, Naoki K, Betsuyaku T.
Organizer
AACR annual meeting
Place of Presentation
San Diego Convention Center(米国、カルフォルニア州)
Year and Date
2014-04-05 – 2014-04-09
Related Report