How does miR-375 promote invasion in non-small-cell lung cancer?

Research Project

Project/Area Number	25870716
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Tumor biology Respiratory organ internal medicine
Research Institution	Keio University
Principal Investigator	YODA Satoshi 慶應義塾大学, 医学部, 共同研究員 (30468491)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords	肺癌 / micro RNA / microRNA / miR-375 / Claudin-1 / 標的遺伝子
Outline of Final Research Achievements	This study was performed concerning microRNAs which regulate the function of genes. We discovered that miR-375, one of microRNAs, regulates the gene named Claudin-1 in non-small cell lung cancer cells. We also reported that stronger expression of miR-375 was related to faster movement of cells and lung cancer patients with stronger expression of miR-375 had shorter survivals. It suggested that miR-375 is involved in metastasis of cancers.

Report

(3 results)