How does miR-375 promote invasion in non-small-cell lung cancer?

• Project/Area Number: 25870716
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Tumor biology; Respiratory organ internal medicine
• Research Institution: Keio University
• Principal Investigator: YODA Satoshi 慶應義塾大学, 医学部, 共同研究員 (30468491)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 肺癌 / micro RNA / microRNA / miR-375 / Claudin-1 / 標的遺伝子

Outline of Final Research Achievements

This study was performed concerning microRNAs which regulate the function of genes. We discovered that miR-375, one of microRNAs, regulates the gene named Claudin-1 in non-small cell lung cancer cells. We also reported that stronger expression of miR-375 was related to faster movement of cells and lung cancer patients with stronger expression of miR-375 had shorter survivals. It suggested that miR-375 is involved in metastasis of cancers.

Research Products

• [Journal Article] Claudin-1 is a novel target of miR-375 in non-small-cell lung cancer. (2014)
  • Author(s): Yoda S, Soejima K, Hamamoto J, Yasuda H, Nakayama S, Satomi R, Terai H, Ikemura S, Sato T, Naoki K, Betsuyaku T.
  • Journal Title: Lung Cancer Volume: 85 Pages: 366-372
  • DOI: 10.1016/j.lungcan.2014.06.009
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Claudin-1, a novel target of miR-375 in non-small cell lung cancer. (2014)
  • Author(s): Yoda S, Soejima K, Yasuda H, Sato T, Arai D, Ohgino K, Ishioka K, Tani T, Oashi A, Kuroda A, Nishino M, Miyawaki M, Hamamoto J, Naoki K, Betsuyaku T.
  • Organizer: AACR annual meeting
  • Place of Presentation: San Diego Convention Center（米国、カルフォルニア州）
  • Year and Date: 2014-04-05 – 2014-04-09