| Project/Area Number |
25870719
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
Digestive surgery
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| Research Institution | Keio University |
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Principal Investigator |
HIRAYAMA Akiyoshi 慶應義塾大学, 政策・メディア研究科, 特任助教 (00572405)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | メタボロミクス / 膵臓がん / バイオマーカー探索 / がん組織 / 血清 / 膵液 / CE-MS / 代謝 / ポリアミン |
|---|
| Outline of Final Research Achievements |
In this study, comprehensive analysis of charged metabolites extracted from pancreatic tumor tissue, pancreatic fluid and blood serum were performed by using capillary electrophoresis-mass spectrometry (CE-MS) in order to discover novel cancer-specific metabolism and biomarker candidates.
As a result, five pancreatic cancer-specific pathways and 24 serum biomarker candidates were highlighted in this study. This information will help to elucidate the metabolic mechanisms underlying pancreatic cancer.
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