The potential mechanisms of EGFR-TKI induced lung injury in mice model
| Project/Area Number |
25870736
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
Tumor biology
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 上皮成長因子受容体阻害剤 / 腫瘍壊死因子 / 肺障害 / ヒト上皮成長因子受容体 / 上皮成長因子受容体 |
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| Outline of Final Research Achievements |
Epidermal Growth Factor Receptor (EGFR) and other ErbB receptors; ErbB2-4, through cytokine and growth factor stimulation, are up-regulated in lung emphysema, pulmonary fibrosis and lung cancer, suggesting that the activation of ErbB receptors is response to emphysema, fibrosis and cancer in humans. TNF is a major inflammatory cytokine with many biological properties including both anti- and pro-apoptotic signaling pathways. However, the molecular switch, which determines TNF regulation of these two different functions, is not well characterized. We previously reported that EGFR and ErbB2 were transactivated by TNF via SRC kinase activity, which promotes the intestinal epithelial cell survival response to TNF. In this study, we elucidate the hypothesis that EGFR/ErbBs activity regulates TNF-mediated bronchial epithelial cell survival and inhibition of EGFR tyrosine kinase activity increase bronchial epithelial cell apoptosis, then finally fibrosing lung tissues in SP-C/TNF tg mice.
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Report
(4 results)
Research Products
(16 results)
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[Presentation] 肺癌患者におけるCOPDの有無による合併症・併存症の比較検討2015
Author(s)
岸野 康成, 村田 泰規, 楠本 壮二郎, 石田 博雄, 白井 崇生, 濱田 和幸, 山岡 利光, 片岡 大輔, 山本 滋, 大西 司, 大森 亨, 佐々木 康綱, 門倉 光隆, 相良 博典
Organizer
日本肺癌学会学術集会
Place of Presentation
横浜
Year and Date
2015-11-26
Related Report
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[Presentation] 進行非小細胞肺癌におけるEGFR-TKIによる薬剤性肺障害と薬物動態および薬理遺伝子多型の関連性の検討2015
Author(s)
廣瀬 敬, 藤田 健一, 大木 康成, 村田 泰則, 楠本 壮二郎, 杉山 智英, 石田 博雄, 白井 崇生, 中嶌 賢尚, 山岡 利光, 奥田 健太郎, 大森 亨, 佐々木 康綱, 田村 厚久, 大田 健
Organizer
日本肺癌学会学術集会
Place of Presentation
横浜
Year and Date
2015-11-26
Related Report
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[Presentation] TNF transactivation of EGFR protects EGFR-TKI, gefitinib induced pulmonary epithelial cell apoptosis and injury in TNF transgenic mice2014
Author(s)
山岡利光, 大森亨, 大木康成, 村田泰規, 楠本壮二郎, 石田博雄, 白井崇生, 廣瀬敬, 大西司, 佐々木康綱
Organizer
日本癌学会
Place of Presentation
横浜
Year and Date
2014-09-25 – 2014-09-27
Related Report
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[Presentation] TNF transactivation of EGFR protects EGFR-TKI, gefitinib induced pulmonary epithelial cell apoptosis and injury in TNF transgenic mice2014
Author(s)
山岡利光, 大木康成, 村田泰規, 楠本壮二郎, 石田博雄, 白井崇生, 外谷衣都子, 大場基, 藤田健一, 荒田悟, 大森亨, 大西司, 相良博典, 佐々木康綱
Organizer
米国 癌学会 (AACR)
Place of Presentation
サンディエゴ
Year and Date
2014-04-05 – 2014-04-09
Related Report
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[Presentation] The characteristics of an acquired dual resistance to EGFR & MET inhibitors in non-small cell lung cancer, harboring active mutation of EGFR2013
Author(s)
山岡 利光, 市橋陽子, 大木 康成, 村田 泰規, 杉山 智英, 石田 博雄, 白井 崇生, 中嶌 賢尚, 奥田 健太郎, 大西 司, 廣瀬 敬, 大森 亨
Organizer
米国癌学会（AACR）
Place of Presentation
ワシントンDC
Related Report
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[Presentation] 小細胞肺癌患者における末梢血中がん細胞数と予後の検討2013
Author(s)
白井 崇生, 廣瀬 敬, 村田 泰規, 大木 康成, 楠本 壮二郎, 杉山 智英, 石田 博雄, 中嶌 賢尚, 山岡 利光, 奥田 健太郎, 大西 司, 大森 亨, 相良 博典
Organizer
日本肺癌学会
Place of Presentation
東京
Related Report
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[Presentation] 非小細胞肺癌におけるエルロチニブとゾレドロン酸併用療法の有用性に関する後方視的解析2013
Author(s)
大木 康成, 廣瀬 敬, 白井 崇生, 村田 泰規, 杉山 智英, 楠本 壮二郎, 石田 博雄, 中嶌 賢尚, 山岡 利光, 奥田 健太郎, 大西 司, 大森 亨, 相良 博典
Organizer
日本肺癌学会
Place of Presentation
東京
Related Report
