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A study of altered neural mechanisms in high-functioning autism using network analysis

Research Project

Project/Area Number 25870738
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Experimental psychology
Perceptual information processing
Research InstitutionShowa University

Principal Investigator

ITAHASHI Takashi  昭和大学, 大学共同利用機関等の部局等, 講師 (70636943)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords自閉症スペクトラム障害 / 安静時脳機能結合 / ネットワーク解析 / マルチモーダル画像解析 / 安静時脳機能ネットワーク / マルチモダリティ神経画像 / 脳機能画像 / 安静時機能的磁気共鳴画像法 / ネットワーク / グラフ理論
Outline of Final Research Achievements

Using magnetic resonance imaging (MRI), I conducted a series of analyses on resting-state functional MRI (rsfMRI), diffusion tensor imaging (DTI), and structural MRI (sMRI), to identify neural mechanisms that underlie social and communicative deficits in autism spectrum disorder (ASD). For rsfMRI analyses, the ASD group showed loss of hubness in several brain regions that are critical for social functions. Furthermore, their functional brain networks tended to show a randomized organization. For analyses of DTI and sMRI, the ASD group showed decreased gray matter (GM) volumes in multiple regions, including the bilateral fusiform gyri and bilateral orbitofrontal cortices. These GM changes were linked with a pattern of decreased fractional anisotropy in several tracts, such as the bilateral inferior longitudinal fasciculi and inferior fronto-occipital fasciculi. These findings help to identify abnormal neural mechanism, which may be characterized social and communicative deficits in ASD.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (3 results)

  • [Journal Article] Linked alterations in gray and white matter morphology in adults with high-functioning autism spectrum disorder: A multimodal brain imaging study2015

    • Author(s)
      Takashi Itahashi, Takashi Yamada, Motoaki Nakamura, Hiromi Watanabe, Bun Yamagata, Daiki Jimbo, Seiji Shioda, Miho Kuroda, Kazuo Toriizuka, Nobumasa Kato, Ryuichiro Hashimoto
    • Journal Title

      NeuroImage: Clinical

      Volume: 7 Pages: 155-169

    • DOI

      10.1016/j.nicl.2014.11.019

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Altered network topologies and hub organization in adults with autism: A resting-state fMRI study2014

    • Author(s)
      Itahashi, T., Yamada, T., Watanabe, H., Nakamura, M., Jimbo, D., Shioda, S., Toriizuka, K., Kato, N., & Hashimoto, R
    • Journal Title

      PLoS ONE

      Volume: 9(4) Issue: 4 Pages: e94115-e94115

    • DOI

      10.1371/journal.pone.0094115

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 成人自閉症スペクトラム障害の安静時脳機能ネットワークにおける重複コミュニティを用いた検討2015

    • Author(s)
      板橋貴史, 山田貴志, 渡部洋実, 中村元昭, 太田晴久, 金井智恵子, 加藤進昌, 橋本龍一郎
    • Organizer
      第 38 回神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-07-28 – 2015-07-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] 成人高機能自閉症の脳活動異常と局所的機能結合異常:安静時fMRIを用いた検討2014

    • Author(s)
      板橋貴史, 山田貴志, 渡部洋実, 中村元昭, 金井智恵子, 加藤進昌, 橋本龍一郎
    • Organizer
      第 37 回神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Altered functional brain networks in adults with autism spectrum disorder2013

    • Author(s)
      Itahashi, T., et al.
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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