Invention of annulation reaction using alkynyl compounds by metal catalysts
| Project/Area Number |
25870747
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Synthetic chemistry
Organic chemistry
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| Research Institution | Chuo University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 不活性結合活性化 / 挿入反応 / 環化反応 / 不飽和結合 / パラジウム / 含酸素環状化合物 / 有機化学 / 挿入 / 環化 / クロマン / ビアリール / イソシアナート / ノルボルネン / ベンゾフラン |
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| Outline of Final Research Achievements |
Collaboration between oxygen-linked alkynyl group and transition-metal catalysts was found to utilize the straightforward activation of stable carbon-hydrogen bonds in alkynyl-containing organic substrates. This methods were applicable to the activation
of arylic, vinylic, and benzylic carbon-hydrogen bonds followed by intramolecular annulation or intermolecular annulation with other unsaturated bonded compounds via an insertion of the oxygen-bonded alkynyl group. These transformations led to various oxacycles. In addition, we obtained the information about reaction mechanisms, which give us hints to use normal alkynyl groups for carbon-hydrogen bond activation with transition-metal catalysts.
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Report
(5 results)
Research Products
(44 results)
