Interaction pair predictor for membrane proteins
| Project/Area Number |
25870764
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
System genome science
Life / Health / Medical informatics
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| Research Institution | Tokyo Denki University |
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Principal Investigator |
Nemoto Wataru 東京電機大学, 理工学部, 准教授 (10455438)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 膜タンパク質 / 相互作用 / バイオインフォマティクス / 予測 / アミノ酸配列 / 立体構造 / 機械学習 / インターフェイス / データベース |
|---|
| Outline of Final Research Achievements |
Membrane proteins are important pharmaceutical targets. Many membrane proteins exert a wide variety of molecular functions by forming their specific combinations. In addition, various membrane proteins are reportedly associated with diseases. Their oligomerization is now recognized as an important event in various biological phenomena, and many researchers are investigating this subject. We have tried to develop a support vector machine (SVM)-based method to predict interacting pairs for membrane protein oligomerization, by integrating their structure and sequence information. However, it is still difficult to develop a method to predict interacting membrane protein pairs among all membrane proteins. Hence, in this project, we focused only on G protein-coupled receptors (GPCRs), and developed a high performance method. Our method could accelerate the analyses of these interactions, and contribute to the elucidation of the global structures of the GPCR networks in membranes.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] DOR; a Database of Olfactory Receptors – Integrated Repository for Sequence and Secondary Structural Information of Olfactory Receptors in Selected Eukaryotic Genomes2014
Author(s)
Balasubramanian Nagarathnam, Snehal D. Karpe, Krishnan Harini, Kannan Sankar, Mohammed Iftekhar, Durairaj Rajesh, Sadasivam Giji, Govidaraju Archunan, Veluchamy Balakrishnan, M. Michael Gromiha, Wataru Nemoto, Kazhuhiko Fukui and Ramanathan Sowdhamini
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Journal Title
Bioinformatics and Biology Insights
Volume: 8
Pages: 147-158
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] DOR ; A Database of Olfactory Receptors2014
Author(s)
Nagarathnam B, Karpe D.S., Harini K, Sankar K, Iftekhar M, Rajesh D, Giji S, Archunan G, Balakrishnan V, Gromiha M, Nemoto W, Fukui K and Sowdhamini R
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Journal Title
Bioinformatics and Biology Insights
Volume: in press
Related Report
Peer Reviewed
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[Presentation] GGIP: GPCR-GPCR Interaction Pair Predictor2016
Author(s)
Wateru Nemoto,Yoshihiro Yamanishi, Limviphuvadh Vachiranee, Akira Saito, Hiroyuki Toh
Organizer
Biophysical Society 60th Annual Meeting
Place of Presentation
Los Angeles Convention Center (Los Angeles, USA)
Year and Date
2016-02-27
Related Report
Int'l Joint Research
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[Presentation] GGIP: GPCR-GPCR Interaction Pair prediction2014
Author(s)
Wataru Nemoto,Yoshihiro Yamanishi,Vachiranee Limviphuvadh,Hiroyuki Toh
Organizer
the 18th Congress of International Union of Pure and Applied Biophysics (IUPAB)
Place of Presentation
BCEC, Brisbane, Australia
Year and Date
2014-08-06
Related Report
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