Development of biomarkers for hazardous material assessments based on lipidomics technique
Project/Area Number |
25870769
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Green/Environmental chemistry
Environmental impact assessment
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Research Institution | Tokyo University of Pharmacy and Life Science |
Principal Investigator |
AOKI MOTOHIDE 東京薬科大学, 生命科学部, 助教 (30418917)
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Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 環境モニタリング / リピドミクス / バイオマーカー |
Outline of Final Research Achievements |
When unexpected environmental pollution is suspected, the pollutants are needed to be quickly identified for evaluating its environmental impacts. Organisms have an ability to adapt to environmental changes by adjusting the biological components. Lipids are one of the major biological components, and environmental changes or diseases have an influence on its composition. We examined whether LC-MSMS analyses can capture the specific change patterns of lipid composition response to a toxic material stresses. Detecting condition of the lipid components was studied as a sample the total lipid extracted from cyanobacteria, and it has been established that analysis method that can be separated and detected simultaneously approximately a hundred and several tens of components. Then, discovery of lipid biomarkers response to some heavy metals exposure is attempted, and some components were successfully found as lipid to increase or decrease more than twice.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Profiling of lipid and glycogen accumulations under different growth conditions in the sulfothermophilic red alga Galdieria sulphuraria.2016
Author(s)
Sakurai, T., Aoki, M., Ju, X., Ueda, T., Nakamura, Y., Fujiwara, S., Umemura, T., Tsuzuki, M., and Minoda, A.
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Journal Title
Bioresource Technology
Volume: 200
Pages: 861-866
DOI
Related Report
Peer Reviewed / Open Access
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