| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Influence of Lactobacillus crispatus KT-11, which isolated from the healthy infant feces, on periodontal disease is as follows:
In, mix culture, several periodontopathogens were killed after viable KT-11 reached maximal cell density. Mice orally infected with Porphyromonas gingivalis (mouse periodontitis model) exhibited significantly more bone loss compared with that of sham-infected mice. Mouse periodontitis model that ingested the KT-11-containing feed was significantly attenuated alveolar bone resorption. Induction of total IgG in plasma and total secretory IgA in saliva was observed. A specific plasma IgG antibody response to P. gingivalis also was induced. Based on the immune response to P. gingivalis infection induced by ingestion of KT-11, this study suggests that oral administration of KT-11 is effective in preventing chronic periodontitis.
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