The novel mechanisms of sonic hedgehog gene expression in the chronic inflammation induced cancer

Research Project

Project/Area Number	25870792
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Tumor biology General medical chemistry
Research Institution	Nippon Medical School
Principal Investigator	Abe Yoshinori 日本医科大学, 付置研究所, 助教 (00386153)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000) Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords	STAT3 / hedgehogシグナル伝達経路 / 肺癌 / hedgehog経路 / 癌化の分子機構 / Hedgehogシグナル伝達経路 / 非小細胞肺癌 / 慢性炎症 / 遺伝子転写制御
Outline of Final Research Achievements	Lung cancer is the most leading cause of cancer death. We found that the expression of sonic hedgehog (Shh) gene, which is a ligand required for hedgehog signaling pathway activation was enhanced in lung cancer-derived cell lines. From subsequent analysis, we found that a transcription factor STAT3, which is involved in the chronic inflammation-induced tumorigenesis, induced Shh gene expression in lung cancer-derived cell lines. This mechanism may play an important role in tumor maintenance.