Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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Outline of Final Research Achievements |
Lung cancer is the most leading cause of cancer death. We found that the expression of sonic hedgehog (Shh) gene, which is a ligand required for hedgehog signaling pathway activation was enhanced in lung cancer-derived cell lines. From subsequent analysis, we found that a transcription factor STAT3, which is involved in the chronic inflammation-induced tumorigenesis, induced Shh gene expression in lung cancer-derived cell lines. This mechanism may play an important role in tumor maintenance.
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