| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Sphingomyelin(SM) is a main component of cellular lipid bylaer membranse and implicates in various cellular functions such as proliferation, migration, and virus infection. The Japanese encephalitis virus (JEV) belongs to the Flaviviridae, infects via mosquitoes, and causes severe encephalitis. The E protein of JEV is necessary for the attachment and infection to target cells.
However, its celllular target factors are unknown. In this study, I showed that deficiency of SM synthesis inhibits JEV infection both cells and mice. This study provides new insight for developing the novel therapeutic approaches to prevention of JEV infection and enchephalitis.
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