| Project/Area Number |
25870860
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontology
Social dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 喫煙 / 歯周炎 / ニコチン代謝能 / CYP2A6 / 遺伝子 / 一塩基多型 / インターロイキン１受容体 / IL1R2 / 遺伝子多型 / ロジスティック回帰分析 / アリル頻度 / IL1受容体 / 喫煙関連歯周炎 |
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| Outline of Final Research Achievements |
Smoking is a strong risk factor the most impact of periodontal disease, nicotine contained in tobacco adversely affect the periodontal disease. Nicotine metabolism in the body is controlled by the Cytochrome P450 (CYP) 2A6. CYP2A6 gene polymorphism can cause a reduction in nicotine metabolism, after smoking, it is allowed to remain long nicotine into the body it has become apparent. However, the relationship between periodontitis and CYP2A6 gene polymorphism of smokers is not clear. In this research subject, from the polymorphism of CYP2A6 gene, the genetic polymorphisms exhibiting low nicotine metabolism type, and genotyped for each subject, the patient - The result of genotype frequencies Analysis among control subjects group, significant difference in the frequency between the two groups was observed.
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