The analysis of lipid metabolism changes by short sleep duration and smoking

• Project/Area Number: 25870868
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied health science; Laboratory medicine
• Research Institution: Nagoya University (2014-2016); Chubu University (2013)
• Principal Investigator: MIYATA Seiko 名古屋大学, 医学系研究科, 寄附講座助教 (40560917)
• Research Collaborator: NODA Akiko 中部大学, 臨床検査技術教育・実習センター, 教授 (80252287) ; TAGUCHI Ryo 中部大学, 生命健康科学部, 教授 (20080210)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 生活習慣病 / 脂質 / 質量分析 / 脂質代謝解析 / 睡眠習慣 / 喫煙習慣 / 脂質解析

Outline of Final Research Achievements

We studied the effect of short sleep duration and smoking on lipid metabolic changes and brain and endothelial function. Three nights of sleep restriction reduced the cortical oxygenation response during cognitive task compared to that in natural sleep. Endothelial function after smoking was significantly impaired than that at rest in young smokers. We identified significant changes of 168, 72 and 39 lipid species between natural sleep and sleep restriction, smokers and non-smokers, and pre- and post-smoking using electrospray ionization mass spectrometry.

Research Products

• [Journal Article] Influence of sleep duration on cortical oxygenation in elderly individuals (2017)
  • Author(s): Kato K, Miyata S, Ando M, Matsuoka H, Yasuma F, Iwamoto K, Kawano N, Banno M, Ozaki N, Noda A
  • Journal Title: Psychiatry Clin Neurosci Volume: 71 Issue: 1 Pages: 44-51
  • DOI: 10.1111/pcn.12464
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Endomyocardial radial strain rate imaging during dobutamine stress echocardiography for the evaluation of contractile reserve in patients with dilated cardiomyopathy (2016)
  • Author(s): Minoshima M, Noda A, Kobayashi M, Miyata S, Hirashiki A, Okumura T, Izawa H, Ishii H, Kondo T, Murohara T.
  • Journal Title: J Clin Ultrasound Volume: 44 Issue: 9 Pages: 555-560
  • DOI: 10.1002/jcu.22376
  • Peer Reviewed / Open Access
• [Journal Article] Masked Hypertension and Morning Blood Pressure Surge in Patients with Obstructive Sleep Apnea Syndrome (2016)
  • Author(s): Miyata S, Noda A, Otake H, Yasuda Y
  • Journal Title: J Sleep Disor: Treat Care Volume: 5 Issue: 01 Pages: 1-5
  • DOI: 10.4172/2325-9639.1000168
  • Peer Reviewed
• [Journal Article] The effect of habitual physical training on left ventricular function during exercise by three-dimensional echocardiography (2015)
  • Author(s): Sugiura Kojima M, Noda A, Miyata S, Kojima J, Hara Y, Minoshima M, Murohara T
  • Journal Title: Echocardiography Volume: 未定 Issue: 11 Pages: 1670-1675
  • DOI: 10.1111/echo.12934
  • Peer Reviewed / Open Access
• [Journal Article] Impaired cortical oxygenation is related to mood disturbance resulting from three nights of sleep restriction (2015)
  • Author(s): Miyata S, Noda A,Iwamoto K, Kawano N, Banno M, Tsuruta Y, Noda Y, Ozaki N.
  • Journal Title: Sleep Biol. Rhythms Volume: 13 Issue: 4 Pages: 387-394
  • DOI: 10.1111/sbr.12130
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Smoking acutely impaired endothelial function in healthy college students (2015)
  • Author(s): MiyataS, Noda A, Ito Y, Iizuka R, Shimokata K
  • Journal Title: Acta Cardiologica Volume: 70 Pages: 282-285
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effects of a custom-made pillow on sleep and blood pressure circadian rhythm (2014)
  • Author(s): Miyata S, Noda A
  • Journal Title: J Hypertens Volume: 3 Issue: 06 Pages: 1-3
  • DOI: 10.4172/2167-1095.1000183
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Development of heart failure assessed by tissue Doppler imaging in hypertensive Dahl rats (2014)
  • Author(s): Miyata S, Yamada A I, Hashimoto K, Kuroki S, Iwamoto T, Noda A
  • Journal Title: Annal Report Research Institute for Biological Function Volume: 10 Pages: 16-22
  • NAID: 120006520345
  • Open Access
• [Journal Article] 睡眠ポリグラフ検査における心電図モニターの役割 (2014)
  • Author(s): 宮田聖子, 野田明子, 大竹宏直
  • Journal Title: 睡眠医療 Volume: 7 Pages: 406-410
• [Journal Article] The effects of acute treatment with paroxetine, amitriptyline, and placebo on the equilibrium function in healthy subjects: a double-blind crossover trial. (2014)
  • Author(s): Miyata S, Noda A, Iwamoto K, Takahashi M, Hara Y, Kojima J, Iidaka T, Ozaki N
  • Journal Title: Int J Psychiatry Clin Pract Volume: 18 Issue: 1 Pages: 32-36
  • DOI: 10.3109/13651501.2013.813551
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effect of aged garlic extract on left ventricular diastolic function and fibrosis in rats model of hypertension (2013)
  • Author(s): Hara Y, Noda A, Miyata S, Minoshima M, Sugiura M, Kojima J, Otake M, Furukawa M, Cheng XW, Nagata K, Murohara T
  • Journal Title: Exp Anim Volume: 62 Pages: 305-310
  • Peer Reviewed
• [Journal Article] Poor sleep quality impaired cognitive performance in older adults (2013)
  • Author(s): Miyata S, Noda A, Iwamoto K, Kawano N, Okuda M, Ozaki N
  • Journal Title: J Sleep Res Volume: 22 Issue: 7 Pages: 535-541
  • DOI: 10.1080/13607863.2013.790930
  • Peer Reviewed
• [Journal Article] Comparison of oxygen desaturation patterns in children and adults with sleep-disordered breathing (2013)
  • Author(s): Hara Y, Noda A, Miyata S, Otake H, Yasuda Y, Okuda M, Koike Y, Nakata S, Nakashima T.
  • Journal Title: Am J Otolaryngol Volume: 34 Issue: 5 Pages: 537-540
  • DOI: 10.1016/j.amjoto.2013.01.014
  • Peer Reviewed
• [Journal Article] 心房細動と睡眠呼吸障害 (2013)
  • Author(s): 宮田聖子, 野田明子, 大竹宏直
  • Journal Title: 睡眠医療 Volume: 7 Pages: 272-275
• [Presentation] REM sleep behavior disorder in late-onset psychiatric disorders: clinical relevance to Lewy body disease (2016)
  • Author(s): Fujishiro H, Okuda M, Iwamoto K, Miyata S, Otake H, Noda A, Iritani S, Ozaki N
  • Organizer: NMDPD 2016 11th International Congress on Non-Motor Dysfunctions in Parkinson’s Disease and Related Disorder
  • Place of Presentation: Ljubljana (Slovenia)
  • Year and Date: 2016-10-06
  • Int'l Joint Research
• [Presentation] 地域在住高齢者における睡眠・睡眠呼吸障害の認知機能への影響 (2016)
  • Author(s): 宮田聖子, 野田明子, 安藤元郎, 松岡弘樹, 岩本邦弘, 藤城弘樹, 奥田将人, 大竹宏直, 宮﨑総一郎, 尾崎紀夫
  • Organizer: 第6回日本認知症予防学会学術集会
  • Place of Presentation: 東北大学(宮城県仙台市)
  • Year and Date: 2016-09-23
• [Presentation] 高齢閉塞性睡眠時無呼吸症患者における睡眠ポリグラフ検査所見とCPAP治療継続への影響の検討 (2016)
  • Author(s): 宮田聖子, 大竹宏直, 藤城弘樹, 奥田将人, 岩本邦弘, 安田宜成, 野田明子, 尾崎紀夫
  • Organizer: 日本睡眠学会第41回定期学術集会
  • Place of Presentation: 京王プラザホテル(東京都新宿区)
  • Year and Date: 2016-07-07
• [Presentation] 中高年発症の精神疾患におけるREM sleep without atoniaの定量評価と臨床症状の関係について (2016)
  • Author(s): 藤城弘樹, 奥田将人, 岩本邦弘, 宮田聖子, 大竹宏直, 野田明子, 尾崎紀夫
  • Organizer: 日本睡眠学会第41回定期学術集会
  • Place of Presentation: 京王プラザホテル(東京都新宿区)
  • Year and Date: 2016-07-07
• [Presentation] 精神科病棟におけるREM sleep without atoniaとレビー小体病の関係について (2016)
  • Author(s): 藤城弘樹, 奥田将人, 岩本邦弘, 宮田聖子, 大竹宏直, 野田明子, 尾崎紀夫
  • Organizer: 日本睡眠学会第41回定期学術集会
  • Place of Presentation: 京王プラザホテル(東京都新宿区)
  • Year and Date: 2016-07-07
• [Presentation] 高齢者閉塞性睡眠時無呼吸症とサルコペニアの関連についての検討 (2016)
  • Author(s): 大竹宏直, 宮田聖子, 藤城弘樹, 奥田将人, 安田宜成, 野田明子, 尾崎紀夫
  • Organizer: 日本睡眠学会第41回定期学術集会
  • Place of Presentation: 京王プラザホテル(東京都新宿区)
  • Year and Date: 2016-07-07
• [Presentation] Influences of patient characters and polysomnographic parameters on a sheet type home screening test (2016)
  • Author(s): Miyata S, Otake H, Fujishiro H, Okuda M, Noda A, Ozaki N
  • Organizer: SLEEP 2016
  • Place of Presentation: Denver (USA)
  • Year and Date: 2016-06-11
  • Int'l Joint Research
• [Presentation] 閉塞性睡眠時無呼吸症候群における耳鼻咽喉科所見とCPAP使用状況の検討 (2016)
  • Author(s): 宮田聖子, 野田明子, 大竹宏直
  • Organizer: 第9回中部睡眠循環呼吸研究会
  • Place of Presentation: ANAクラウンプラザホテルグランコート名古屋(愛知県名古屋市)
  • Invited
• [Presentation] 食塩感受性Dahlラットにおける水素ガスの高血圧への影響 (2015)
  • Author(s): 宮田聖子, 加藤和子, 野田明子
  • Organizer: 第38回日本高血圧学会総会
  • Place of Presentation: 愛媛県県民文化会館(愛媛県松山市)
  • Year and Date: 2015-10-09
• [Presentation] 睡眠不足と認知機能低下・気分障害との関係 (2015)
  • Author(s): 宮田聖子, 野田明子
  • Organizer: 第5回日本認知症予防学会学術集会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2015-09-25
• [Presentation] 長期follow up による小児閉塞性睡眠時無呼吸症候群の手術後身体発育に関する検討 (2015)
  • Author(s): 3.大竹宏直, 多賀谷満彦, 藤城弘樹, 宮田聖子, 奥田将人, 藏本絵理佳, 山本浩志, 野田明子, 中田誠一, 尾崎紀夫
  • Organizer: 日本睡眠学会第40回定期学術集会
  • Place of Presentation: 栃木県総合文化センター(栃木県宇都宮市)
  • Year and Date: 2015-07-02
• [Presentation] REM sleep without atonia を呈した症例の臨床的特徴：レビー小体病との関係について (2015)
  • Author(s): 4.藤城弘樹, 奥田将人, 岩本邦弘, 大竹宏直, 宮田聖子, 蔵本絵理佳, 野田明子, 尾崎紀夫
  • Organizer: 日本睡眠学会第40回定期学術集会
  • Place of Presentation: 栃木県総合文化センター(栃木県宇都宮市)
  • Year and Date: 2015-07-02
• [Presentation] 高齢者における簡易近赤外線スペクトロスコピー所見の検討 (2015)
  • Author(s): 5.加藤和子, 野田明子, 本多久美子, 松岡弘樹, 河野直子, 岩本邦弘, 宮田聖子, 奥田将人, 藤城弘樹, 大竹宏直, 尾崎紀夫
  • Organizer: 日本睡眠学会第40回定期学術集会
  • Place of Presentation: 栃木県総合文化センター(栃木県宇都宮市)
  • Year and Date: 2015-07-02
• [Presentation] 閉塞性睡眠時無呼吸症候群における高齢期患者の病態生理に関する検討 (2014)
  • Author(s): 宮田聖子, 野田明子, 奥田将人, 大竹宏直
  • Organizer: 第7回中部睡眠循環呼吸研究会
  • Place of Presentation: ANAクラウンプラザホテルグランコート名古屋 (愛知県名古屋市)
  • Year and Date: 2014-09-13
  • Invited
• [Presentation] 短時間睡眠による昼間の生活および精神機能への影響の検討 (2014)
  • Author(s): 宮田聖子, 野田明子, 尾崎紀夫
  • Organizer: 日本睡眠学会第39回定期学術集会
  • Place of Presentation: あわぎんホール (徳島県徳島市)
  • Year and Date: 2014-07-03 – 2014-07-04
  • Invited
• [Presentation] レビー小体病の補助診断に睡眠ポリグラフ検査が有用であった二例 (2014)
  • Author(s): 大橋知明, 棟近孝之, 藤城弘樹, 奥田将人, 大竹宏直, 岩本邦弘, 宮田聖子, 入谷修司, 野田明子, 尾崎紀夫
  • Organizer: 日本睡眠学会第39回定期学術集会
  • Place of Presentation: あわぎんホール (徳島県徳島市)
  • Year and Date: 2014-07-03 – 2014-07-04
• [Presentation] Relation between excessive daytime sleepiness and cortical oxygenation during cognitive function task (2013)
  • Author(s): Miyata S, Noda A, Iwamoto K, Ozaki N
  • Organizer: SLEEP 2013 Meeting
  • Place of Presentation: Baltimore USA
• [Presentation] 大学生における運動習慣と認知機能との関係 (2013)
  • Author(s): 奥村望, 渡辺拓弥, 宮田聖子, 野田明子
  • Organizer: 第19回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 仙台