| Project/Area Number |
25870891
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
General physiology
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| Research Institution | Kyoto Sangyo University |
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Principal Investigator |
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| Research Collaborator |
WESS Jurgen National Institute of Diabetes and Digestive and Kidney Diseases, Laboratory of Bioorganic Chemistry
YAMADA Masahisa 沖縄科技研基盤整備機構, コモンリソースグループ
KITAZAWA Takio 酪農学園大学, 動物看護学ユニット, 教授
UNNO Toshihiro 岐阜大学, 応用生物科学部, 教授
KOMORI Seiichi 岐阜大学, 応用生物科学部, 名誉教授
MATSUYAMA Hayato 岐阜大学, 応用生物科学部, 准教授
NAGANO Hiroshi 岐阜大学, 連合獣医学研究科, 博士後期課程学生
TAKEUCHI Minoru 京都産業大学, 総合生命科学部, 教授
MURAKAMI Yuri 京都産業大学, 総合生命科学部, 学部学生
WANG Ban 京都産業大学, 総合生命科学部, 学部学生
ONO Maiki 京都産業大学, 総合生命科学部, 学部学生
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | ATP感受性K+チャネル / ムスカリン受容体 / コリン作動性神経 / 腸管運動 / 平滑筋細胞 / ATP感受性Kチャネル / 細胞内情報伝達分子 / SKF96365 / 陽イオンチャネル / 電位依存性Kチャネル / 分子実態 / 薬理学 / 生理学 / シグナル伝達 / ＡＴＰ感受性Ｋチャネル / 腸管平滑筋細胞 / カハール細胞 |
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| Outline of Final Research Achievements |
The aim of this study was to elucidate the physiological roles of ATP-sensitive K+ channels (KATP channels) in muscarinic regulation of intestinal contractility and its mechanism. In addition, the properties of this channel were characterised. The results suggested that (1) the properties of the KATP channel, expressed in the intestinal smooth muscles, are similar to those of the Kir6.1/ SUR2B KATP channel in the vascular smooth muscles, and (2) M3 muscarinic subtype can inhibit the activities of the KATP channel, thereby contributing to the membrane depolarisation in smooth muscles, leading to their contraction.
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