| Project/Area Number |
25870892
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
Tumor biology
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| Research Institution | Kobe Pharmaceutical University (2014)
Kyoto Sangyo University (2013) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KUROSAKA Akira 京都産業大学, 総合生命科学部, 教授 (90186536)
NAKAMURA Naosuke 京都産業大学, 総合生命科学部, 講師 (30424964)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | マクロピノサイトーシス / 低栄養環境 / 腫瘍細胞 |
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| Outline of Final Research Achievements |
The adaptation of cancer cells to malnutrition environment leads to malignant progression. The detailed mechanism of adaptation is an important issue to explore a new target molecule for anti-cancer agents. In this study, we focused on macropinocytosis, which is a process of extracellular fluid uptake, and is observed characteristically in tumor cells. We hypothesized that macropinocytosis is involved in the malignant progression, and attempted to clarify its molecular mechanism. The excess addition of sugars or albumin protein suppressed macropinocytosis in certain tumor cells, suggesting that tumor cells may utilize extracellular sugars and proteins by macropinocytosis in response to nutrient environment.
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