| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
This study aimed to clarify the relation between the neurosteroid allopregnanolone (ALLO) and itch in atopic dermatitis (AD), and to provide a new therapeutic target for AD itch. ALLO administration significantly increased scratching behavior in AD model mice, but not in normal ones. Pharmacological analysis showed that GABAA receptor activation in the brain contributes to ALLO-induced scratching in AD mice. It has been reported that ethanol increases ALLO in the brain. Pretreatment with a synthetic inhibitor of ALLO, finasteride, suppressed ethanol-induced scratching in AD mice. Therefore, our findings indicate that endogenously produced ALLO may be involved in itch under AD conditions.
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