| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
During brain formation, post-mitotic neurons migrate through the developing vascular network. To analyze their interaction, we first analyzed the mechanisms that control the morphological changes of migrating neurons. By using the ex vivo slice culture system of the cerebral cortex, it became clear that Cdk5, p27kip1, JNK etc. are involved. We also attempted time-lapse observation to analyze the detailed formation process of the vascular network. However, since the vascular network collapsed early in the slice tissue, we failed to record the normal morphological changes and analyze the molecular mechanism.
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