| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We suggested that propofol, thiopental and midazolam inhibits amyloid β-protein assembly by decreasing GM1 ganglioside expression in detergent-resistant membrane microdomains of neurons, and that leptin inhibits amyloid β-protein assembly by decreasing GM1 ganglioside expression in neuronal membrane.
We suggested that ketamine suppresses Aβ degradation of NEP by reducing p38 MAPK-mediated pathway activity, and that leptin decreases Aβ degradation by NEP through activation of ERK, and that simvastatin and atorvastatin induce the increase of Aβ degradation of NEP on the extracellular of astrocytes by inducing ERK-mediated pathway activity and that these reagents regulate the differential mechanisms between the secretion of NEP, the induction of cholesterol reduction, and the morphological changes in the cultured astrocytes.
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