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Development of oral devices given antibacterial property by fluoride and silver dual ion implantation and deposition method

Research Project

Project/Area Number 25870926
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Prosthodontics/ Dental materials science and
Dental engineering/Regenerative dentistry
Research InstitutionOsaka Dental University

Principal Investigator

SHINONAGA Yukari  大阪歯科大学, 歯学部, 講師 (70531961)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsプラズマイオン注入 / フッ素 / 銀 / 抗菌性 / 表面物性 / 義歯 / 咬合誘導装置 / イオン注入
Outline of Final Research Achievements

The purpose of this research was to create the antibacterial oral devices by fluoride and silver ions implantation using a hybrid process of plasma-based ion implantation and deposition (PBII&D).Poly methyl methacrylate (PMMA) plates were used as the control PMMA group. The PMMA plates were modified by PBII&D. A 99.8% Ag mesh cover was placed 10 mm above the PMMA plates and then sputtered by octafluoropropane gas. For evaluationof the samples, the surface analysis and antibacterial test. The luminescence intensity of the S. aureus suspension in contact with the fluoride-silver ion implanted specimens after 12 hours incubationwas significantly lower than that of the suspension in contact with the control-PMMA specimens.Antibacterial activity was remarkably enhanced in the F and Ag dual-ion implanted and deposited PMMA, which highlights the potential of this method for imparting antibacterial properties to medical and dental devices.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (12 results)

All 2015 2014 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (9 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Effects of porous-hydroxyapatite incorporated into glass-ionomer sealants2015

    • Author(s)
      Shinonaga Y, Arita K, Nishimura T, CHIU SY, CHIU HH, Abe Y, Sonomoto M, Harada K, Nagaoka N
    • Journal Title

      Dental Materials Journal

      Volume: 34 Pages: 196-202

    • NAID

      130005062414

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alterations in Deciduous Dental Pulp Cells Cultured with Serum-free Medium2015

    • Author(s)
      Harada K, Kawai S, Xu Wen-an, Xu liang, Sonomoto M, Shinonaga Y, Abe Y, Ohura K, Zhao Wanghong, Arita K
    • Journal Title

      Journal of Hard Tissue Biology

      Volume: 24 Pages: 17-22

    • NAID

      130004848441

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Porous Hydroxyapatite Can Improve Strength and Bioactive Functions of Glass Ionomer Cement2014

    • Author(s)
      Nishimura T, Shinonaga Y, Abe Y, Kawai S, Arita K
    • Journal Title

      Nano Biomedicine

      Volume: 6 Pages: 53-62

    • NAID

      130005130558

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Morphological characteristics of novel apatite-ionomer cement2015

    • Author(s)
      Arita K,Shinonaga Y,Chiu SY, Chiu HH, Nishimura T, Abe Y, Kawai S, Hitomi S, Sonomoto M, Daito K, Harada K
    • Organizer
      FDI 2015 Annual World Dental Congress
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2015-09-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ability of multi-mineral-ion release from novel Apatite-Ionomer-Cement2014

    • Author(s)
      Y. Shinonaga, T. Nishimura, S. Chiu, H. Chiu, Y. Abe, K. Arita
    • Organizer
      Academy of Dental Materials Annual Meeting (ADM 2014)
    • Place of Presentation
      Bologna,Italy
    • Year and Date
      2014-10-08 – 2014-10-11
    • Related Report
      2014 Research-status Report
  • [Presentation] シーラント用アパタイトアイオノマーセメントの各種イオン溶出に関する研究2014

    • Author(s)
      邱 秀慧,邱 思瑜,西村貴子,鄭 佳佳,篠永ゆかり
    • Organizer
      第33回日本小児歯科学会近畿地方会大会および総会
    • Place of Presentation
      大阪市,大阪歯科大学100周年記念館
    • Year and Date
      2014-10-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Porous hydroxyapatite can improve strength and bioactive functions of glass ionomer cement2014

    • Author(s)
      Takako Nishimura,Yukari Shinonaga, Yoko Abe, Saki Kawai, Kenji Arita
    • Organizer
      9th Biennial Conference of the Pediatric Dentistry Association of Asia (PDAA 2014)
    • Place of Presentation
      Singapore
    • Year and Date
      2014-08-22 – 2014-08-24
    • Related Report
      2014 Research-status Report
  • [Presentation] ハイドロキシアパタイトを含有した新規グラスアイオノマーセメントの機能性評価2014

    • Author(s)
      篠永ゆかり,河合咲希,原田京子,有田憲司
    • Organizer
      第34回日本歯科薬物療法学会学術大会
    • Place of Presentation
      大阪市,大阪歯科大学100周年記念館
    • Year and Date
      2014-06-21
    • Related Report
      2014 Research-status Report
  • [Presentation] 新規アパタイトアイオノマーセメントの元素溶出能についての検証2014

    • Author(s)
      篠永 ゆかり,西村 貴子,邱 秀慧,邱 思瑜,阿部洋子,有田 憲司
    • Organizer
      第52回日本小児歯科学会大会
    • Place of Presentation
      東京都,品川区総合区民会館きゅりあん
    • Year and Date
      2014-05-16 – 2014-05-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 歯質保護用GICフジVIIへのハイドロキシアパタイト添加の有効性2013

    • Author(s)
      西村 貴子,篠永 ゆかり,有田 憲司
    • Organizer
      第51回日本小児歯科学会大会
    • Place of Presentation
      岐阜市,長良川国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] Effects on property of posterior glass-ionomer-restorative-cement by hydroxyapatite addition2013

    • Author(s)
      T. NISHIMURA, Y. SHINONAGA, S. CHIU, H. CHIU, K. ARITA
    • Organizer
      46th Meeting of the Continental European Division of the IADR with the Scandinavian Division
    • Place of Presentation
      Florence, Italy
    • Related Report
      2013 Research-status Report
  • [Presentation] Antibacterial property of New Apatite-Ionomer Cement for ART Sealants2013

    • Author(s)
      Y. SHINONAGA, T. NISHIMURA, H. CHIU, S. CHIU, K. ARITA
    • Organizer
      46th Meeting of the Continental European Division of the IADR with the Scandinavian Division
    • Place of Presentation
      Florence, Italy
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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