| Project/Area Number |
25870955
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological physics/Chemical physics/Soft matter physics
Dermatology
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| Research Institution | Kwansei Gakuin University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 皮膚角層バリア機能 / 細胞間脂質 / 放射光X線回折 / 経皮吸収 / 皮膚角層 / 経皮水分蒸散量 / TEWL / X線回折 / バリア機能 / X線散乱 |
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| Outline of Final Research Achievements |
Stratum corneum (SC) is mainly composed of flattened corneocytes and highly ordered intercellular lipid lamellar region in the outermost layer of the human skin. The SC serves as a physicochemical barrier to percutaneous absorption of not only harmful agents but also drugs (for example, ointment for skin). In order to develop drugs with more effective absorption properties, it is important to clarify the interaction between the SC and drugs at the molecular level. In this study, we developed a sample cell designed for the simultaneous analysis of the SC structure and skin permeation, and made clear the behavior of water in SC. By conducting a detailed analysis of the interaction between the SC and the drugs, this study aims to elucidate the percutaneous absorption mechanism of drugs.
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