Antitumor effect of newly synthesized naftopidil derivatives on malignant pleural mesothelioma.

Research Project

Project/Area Number	25870965
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Tumor therapeutics Respiratory organ internal medicine
Research Institution	Hyogo Medical University
Principal Investigator	KANNO TAKESHI 兵庫医科大学, 医学部, 准教授 (20434946)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000) Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	悪性胸膜中皮腫 / ナフトピジル誘導体
Outline of Final Research Achievements	We newly synthesized 21 naftopidil derivatives, and of them 1-[2-(2-methoxyphenylamino) ethylamino]-3-(naphthalene-1-yloxy)propan-2-ol (HUHS1015) most efficiently reduced cell viability for all the investigated malignant mesothelioma cell lines NCI-H28, NCI-H2052, NCI-H2452,and MSTO-211H. HUHS1015 clearly suppressed tumor growth in mice inoculated with NCI-H2052 cells. Taken together, the results of the present study indicate that HUHS1015 could be developed as an effective anticancer drug for treatment of malignant pleural mesothelioma.

Report

(3 results)