Antitumor effect of newly synthesized naftopidil derivatives on malignant pleural mesothelioma.
Project/Area Number |
25870965
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Tumor therapeutics
Respiratory organ internal medicine
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Research Institution | Hyogo Medical University |
Principal Investigator |
KANNO TAKESHI 兵庫医科大学, 医学部, 准教授 (20434946)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 悪性胸膜中皮腫 / ナフトピジル誘導体 |
Outline of Final Research Achievements |
We newly synthesized 21 naftopidil derivatives, and of them 1-[2-(2-methoxyphenylamino) ethylamino]-3-(naphthalene-1-yloxy)propan-2-ol (HUHS1015) most efficiently reduced cell viability for all the investigated malignant mesothelioma cell lines NCI-H28, NCI-H2052, NCI-H2452,and MSTO-211H. HUHS1015 clearly suppressed tumor growth in mice inoculated with NCI-H2052 cells. Taken together, the results of the present study indicate that HUHS1015 could be developed as an effective anticancer drug for treatment of malignant pleural mesothelioma.
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Report
(3 results)
Research Products
(4 results)
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[Journal Article] Newly synthesized anticancer drug HUHS1015 is effective on malignant pleural mesothelioma.2014
Author(s)
Kaku Y, Nagaya H, Tsuchiya A, Kanno T, Gotoh A, Tanaka A, Shimizu T, Nakao S, Tabata C, Nakano T, Nishizaki T.
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Journal Title
Cancer science
Volume: 105
Issue: 7
Pages: 883-889
DOI
Related Report
Peer Reviewed
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