| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
It is known in bacteria that expression of genes involved in environmental adaptation is regulated at the level of transcription as well as post-transcriptionally. In this study, I examined the post-transcriptional control of the genes necessary for adaptation to iron starvation in Vibrio parahaemolyticus. As a result, it was revealed that the V. parahaemolyticus peuA gene encoding a receptor for siderophore enterobactin, which is a high affinity iron chelator engaged in iron acquisition, is regulated by translational control. Moreover, I studied whether the genes encoding type III secretion system (T3SS), which is a major virulence factor of V. parahaemolyticus, are regulated post-transcriptionally. As a result, it was disclosed that the small RNA Spot 42 post-transcriptionally regulates the expression of VP1682 in V. parahaemolyticus, which functions as a chaperone for the T3SS effector VP1680.
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